Parkinson's Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 25 and 75 years old
- You have been diagnosed with Parkinson's disease that has no known cause (called "idiopathic" Parkinson's disease)
- A specialist doctor has determined that your current Parkinson's medications have not given you enough relief
- You have asked about having brain stimulation surgery (deep brain stimulation) for your Parkinson's, or you were previously enrolled in a related study and still have significant symptom fluctuations during the day or trouble sleeping despite having your stimulator settings optimized
- Your brain MRI before surgery came back normal
- You do not have significant memory or thinking problems (a score of 24 or higher on a standard memory and thinking test)
- You are willing and able to sign a consent form agreeing to take part
- Your Parkinson's movement symptoms fall within a specific range of severity, and your symptoms improve significantly with Parkinson's medication, with stiffness and slowness being your main problems rather than tremor (confirm with trial site)
- Despite being on the best medication possible, you still experience at least 2 hours per day where your symptoms are poorly controlled or you have uncontrolled involuntary movements
- You are able to attend follow-up visits for brain monitoring, stimulation testing, and clinical check-ups
Who may not be able to join:
- You have blood clotting problems, very high blood pressure that is not controlled, heart disease, or another health condition that could make surgery risky
- Your movement symptoms are thought to be caused by psychological rather than neurological reasons
- You are pregnant (women who could become pregnant will be given a pregnancy test before any surgery)
- You have significant untreated depression, a history of a suicide attempt, or current thoughts of suicide
- You have personality or mood-related symptoms that staff believe would make it difficult for you to take part in the study
- You need certain other medical treatments (such as electroconvulsive therapy, a type of brain stimulation called repetitive transcranial magnetic stimulation, or a heating treatment called diathermy), have other implanted brain stimulators, have metal implants that are not safe for MRI scans, have had previous brain surgery on the side where the device would be placed, or have a problem with drug or alcohol misuse
- You have previously had harmful or unwanted side effects from deep brain stimulation or a similar device
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Simon Little, University of California, San Francisco
Phone: 5175152739
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in number of bothersome movement and/or sleep episodes on adaptive deep brain stimulation compared to open-loop deep brain stimulation
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.