Phase 2 Type 1 Diabetes Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People who have had their lung cancer confirmed through a tissue or cell sample, and whose cancer type is non-small-cell lung cancer (NSCLC)
• People who have not previously received any cancer treatment such as chemotherapy, immunotherapy, or radiotherapy (traditional Chinese herbal medicine used for cancer is allowed if it was stopped at least 2 weeks before the first dose)
• People whose cancer has been assessed by a doctor as surgically removable, at Stage II to IIIB (excluding a specific spread pattern called N3), based on standard cancer staging guidelines
• People whose cancer does not have certain genetic changes (called EGFR mutations, ALK rearrangements, or other targetable mutations) that would normally direct treatment toward a specific approved targeted therapy
• People whose cancer tests negative for a protein called PD-L1 (measured by specific approved tests)
• People whose general physical health is rated at a level meaning they are fully active or have only minor limitations in daily activity (confirm with trial site)
• People whose blood counts, kidney function, liver function, and clotting measures fall within acceptable ranges when tested within 7 days before the first dose (confirm with trial site for specific values)
• People whose lung function tests meet required thresholds, or where a doctor has judged that lung reserve is sufficient for planned surgery (confirm with trial site)
• Women who are able to become pregnant must have a negative blood pregnancy test within 7 days before the first dose
• People who are able to become pregnant, and men whose partners are able to become pregnant, must use a highly effective form of contraception from 7 days before the first dose until 24 weeks after the last dose

Who may not be able to join:

• People who have had major chest or abdominal surgery within the 28 days before the first dose, or who have not fully recovered from a previous surgery
• People who have taken moderate-to-high dose steroid tablets or other immune-suppressing medicines for 7 or more days in a row within the 14 days before the first dose (inhaled or skin-applied steroids, or low-dose steroids for a hormone-related condition, may be permitted — confirm with trial site)
• People who have received a live vaccine within 28 days before the first dose
• People who currently have, or have previously had, a lung inflammation condition called interstitial pneumonia that required steroid treatment
• People with an active autoimmune disease or a history of autoimmune disease, with some exceptions such as well-controlled Type 1 diabetes, stable thyroid underactivity managed with hormone replacement, or mild skin conditions not requiring systemic treatment (confirm with trial site)
• People who have had another cancer within the 5 years before the first dose, unless a doctor has assessed it as fully cured
• People with certain uncontrolled health conditions, including: active hepatitis B or C infection at certain levels; known HIV or a history of AIDS; active tuberculosis; a serious infection requiring antibiotic treatment for more than 7 days within the past 28 days; significant heart or blood vessel disease such as a recent stroke, heart attack, unstable chest pain, serious heart failure, or a heart rhythm problem; or significant protein in the urine
• People who have previously received a bone marrow or organ transplant from another person
• People with a history of a severe allergic reaction (Grade 3 or higher) to antibody-based medicines, a history of anaphylaxis, uncontrolled asthma, or significant drug allergies
• People who are pregnant or breastfeeding
• People with certain other conditions that may affect safety or ability to follow the treatment plan, including serious mental health conditions, large uncontrolled fluid build-up around organs, or fluid that keeps returning and requires repeated draining (such as around the lungs, heart, or in the abdomen)

Important: Always verify eligibility with the trial site directly before applying.