Phase 3 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with high-risk or borderline resectable pancreatic cancer, confirmed through a tissue or cell sample test
• People aged 18 to 75 years old (inclusive)
• People who do not carry mutations in the BRCA1, BRCA2, or PALB2 genes
• People who have not previously had surgery, drug treatment, or radiation therapy for pancreatic cancer
• People with a good general level of physical functioning, rated 0 or 1 on a standard oncology scale (ECOG scale)
• People with a life expectancy of at least 6 months
• People who have at least one tumour that can be measured using standard imaging criteria (RECIST v1.1)
• People whose organs and bone marrow are functioning at adequate levels
• Women who are able to become pregnant and are willing to use effective contraception during the trial

Who may not be able to join:

• People whose cancer has spread to distant parts of the body
• People who have received a blood transfusion, blood products, or blood-boosting medications (such as albumin or G-CSF) within the 14 days before joining
• People who have had surgery or another invasive procedure within 4 weeks before joining (minor procedures such as a venous catheter, needle biopsy, or drainage may be exceptions — confirm with trial site)
• People with a known allergy to the study drug or any of its ingredients
• People with electrolyte (blood mineral) abnormalities considered clinically significant by the trial doctors
• People with a history of serious heart or stroke-related conditions
• People with an active stomach or intestinal ulcer, a hole in the intestine, or a bowel blockage
• People with uncontrolled fluid build-up in the abdomen (ascites) that cannot be managed with water tablets or drainage
• People with active bleeding or a clear tendency to bleed
• People with high blood pressure that cannot be controlled with medication (systolic at or above 150 mmHg and/or diastolic at or above 100 mmHg)
• Women who are pregnant or breastfeeding
• People with significant amounts of protein detected in their urine (at or above a certain threshold on testing)
• People who have had another cancer diagnosis within the past 5 years, with the exception of certain treated early-stage cancers such as cervical carcinoma in situ or basal cell skin cancer
• People who have difficulty swallowing or absorbing oral medications, or who are unable to take medications by mouth
• People with a known HIV infection
• People with significant liver disease, including active hepatitis B or C infection with detectable virus levels, or cirrhosis
• People who have any other medical condition, abnormal test result, or other circumstance that the trial doctors consider would make participation unsuitable

Important: Always verify eligibility with the trial site directly before applying.