Phase 1 Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with cancer that has spread to the lining of the lungs (pleura), or mesothelioma, confirmed by a biopsy, and you are experiencing fluid build-up around the lungs.
• You have already tried standard treatments for your cancer type and those treatments are no longer working or you have exhausted available options.
• You are aged 18 or older but younger than 80.
• If you are a woman who could become pregnant, you must have a negative pregnancy test and agree to use an approved form of contraception for at least 12 months after treatment.
• If you are a man, you must agree to use birth control from the time you join the study until 4 months after receiving the treatment.
• Your heart is pumping at a healthy enough level, confirmed by a specific heart scan (confirm with trial site).
• You do not need extra oxygen to breathe and do not feel breathless right after fluid is drained from around your lungs.
• You are generally well enough to carry out daily activities with little to no limitation (confirm with trial site).
• Doctors expect you to live for more than 12 weeks.
• You are able to understand the risks of the trial and can give your own consent to participate.
• You agree to allow your personal and health information to be collected as part of the study.

Who may not be able to join:

• You have HIV with detectable levels of the virus in your blood (however, those with HIV whose virus is undetectable due to medication may still be considered).
• You have an active Hepatitis B infection with detectable virus in your blood.
• You have an active Hepatitis C infection with detectable virus in your blood.
• You are currently being treated for a bacterial, fungal, or viral infection.
• You have had a heart attack within the last 6 months, or you have active heart or heart valve disease, or an uncontrolled irregular heartbeat.
• You have taken an experimental drug within the 30 days before the fluid collection procedure.
• You have received chemotherapy or radiation therapy within 2 weeks before the fluid collection (this does not apply to certain immunotherapy drugs — confirm with trial site).
• You have been taking steroid medications above a certain dose within the 2 weeks before the fluid collection (confirm with trial site for specific dose details).
• You are taking immune-suppressing medications that cannot safely be stopped for 4 weeks before the fluid collection, as determined by your doctor.
• Your blood test results show significant problems with your liver, kidneys, or blood counts that fall outside acceptable ranges (confirm with trial site for specific values).
• You are pregnant or currently breastfeeding.
• You have previously had a solid organ transplant (such as a kidney, liver, or heart transplant).
• The trial team believes you may not be able to follow the study schedule or procedures.
• You belong to a group considered vulnerable (such as prisoners or those with a developmental disability), or you have any condition that prevents you from giving informed consent or following the study requirements.
• You have had a severe allergic reaction (anaphylaxis) to penicillin.

Important: Always verify eligibility with the trial site directly before applying.