Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People whose general health and ability to carry out daily activities falls within an acceptable range, as measured by a standard medical scale called ECOG (scores 0–2)
• People who have been diagnosed with rectal cancer (a specific type called adenocarcinoma) confirmed by a biopsy
• People whose tumour is located in the lower part of the rectum, within 10 cm of the opening of the bowel
• People whose cancer has not spread to other parts of the body
• People whose cancer is classified as stage II or III based on an MRI scan (a specific sub-type called T4b is not included)
• People whose rectal tumour measures at least 10 mm across on a CT or MRI scan
• People who are willing and able to follow all the requirements of the study
• People who are willing to provide blood and tissue samples for research purposes
• People who have not had any previous cancer treatment, such as radiotherapy, chemotherapy, immunotherapy, or herbal therapy
• People who have no history of immune system conditions (such as lupus, rheumatoid arthritis, ulcerative colitis, or HIV infection, among others)
• People whose heart, lungs, liver, and kidneys are all functioning adequately
• People who do not have jaundice or a blockage in their bowel
• People who do not have an active infection at the time of joining
• People whose blood counts and organ function test results meet specific minimum levels set by the trial (confirm with trial site for exact values)
• People who do not have any social or mental health conditions that could interfere with taking part in the study
• Women who could become pregnant must have a negative pregnancy test before joining and must use effective contraception from the start of the study until at least 60 days after the last dose of the study treatment

Who may not be able to join:

• People who have had more than one type of cancer, or who currently have another cancer alongside rectal cancer
• People who have received any cancer treatment — including surgery, chemotherapy, or radiotherapy — within the past 5 years
• People who have recently had major surgery
• People who have difficulty swallowing, persistent nausea or vomiting, or chronic diarrhoea, which may affect how the body absorbs one of the study medications (capecitabine)
• People with serious or poorly controlled health conditions of any kind
• People who are known to have an allergy or sensitivity to any of the study drugs
• People whose life expectancy is estimated at 5 years or less due to any health condition
• People who have had, or are planning to have, an organ or bone marrow transplant
• People who have used immunosuppressive medications or steroid medicines (for immune-suppressing purposes) within the month before joining
• People with a history of neurological or brain conditions that could affect their ability to give informed consent or follow instructions about taking oral medication (the trial doctor would assess this)
• People with conditions such as alcohol dependence or drug misuse that could interfere with the study results
• Women who are pregnant, breastfeeding, or planning to become pregnant during the treatment period

Important: Always verify eligibility with the trial site directly before applying.