Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older
• You have been diagnosed with a specific type of colorectal cancer (adenocarcinoma) that has spread to other parts of the body, confirmed by a tissue or cell sample
• Your cancer has been tested for certain genetic markers (RAS, BRAF, and MSI/dMMR status) and results are available
• Your cancer has gotten worse or you could not tolerate at least 2 previous treatments for advanced cancer, which must have included certain standard chemotherapy drugs and a specific type of targeted therapy — and additional treatments depending on your cancer's genetic profile
• You have at least one area of cancer that can be measured on a scan, as defined by standard medical guidelines
• You are willing and able to have tumor biopsies (tissue samples) taken during the trial (low-risk biopsies are required; moderate-risk ones are optional; high-risk ones will not be done)
• You are generally well enough to carry out light activity and care for yourself (this is measured using a standard scale called ECOG, score 0 or 1)
• Your blood counts, liver function, kidney function, and other blood test results meet specific minimum levels (confirm with trial site)
• Enough time has passed since your last cancer treatment, radiation, surgery, or other local procedures (specific waiting periods apply depending on the treatment type — confirm with trial site)
• Any side effects from previous cancer treatment have mostly resolved to mild or no symptoms (some exceptions apply, such as hair loss or mild nerve tingling in the hands/feet)
• If you previously had Hepatitis C, your treatment is completed, it ended at least one month ago, and the virus is no longer detectable in your blood
• If you have Hepatitis B, it is being treated and well controlled, with virus levels below a certain threshold in your blood
• Your blood pressure is adequately controlled (at or below 150/90 mmHg), with or without blood pressure medication, and your medication has not changed in the week before starting the trial

Who may not be able to join:

• You are currently receiving other cancer treatments or experimental therapies
• You are taking certain medications that strongly affect how the body processes drugs (called CYP3A4/5 inhibitors or inducers) and cannot stop taking them before the trial starts
• You have a known inherited condition called Gilbert's syndrome or another genetic condition affecting a specific liver enzyme (UGT1A1) (confirm with trial site)
• You have had a serious allergic reaction to drugs similar to the ones used in this trial, or to certain yellow food dyes (FD&C Yellow No. 5 or No. 6)
• You have or have had another active cancer, with some exceptions (such as certain skin cancers treated successfully, cancers fully treated more than 3 years ago, or slow-growing cancers that have never needed treatment)
• You do not have suitable vein access for blood draws or receiving the trial drug, or have a condition that would make drug delivery or sample collection difficult
• You are unable to swallow capsules or tablets
• Your cancer has spread to the brain or the lining around the brain or spinal cord
• You have an active or ongoing infection (other than controlled Hepatitis B)
• You have large swollen veins (varices) at risk of serious bleeding that are not being managed with standard treatments
• You have had a blood clot, stroke, or similar serious blood vessel event within the past 6 months
• You have significant heart problems, including poorly controlled heart failure, unstable chest pain, irregular heartbeat, certain abnormal heart rhythm measurements on an ECG, a history of a specific heart rhythm disorder, or a heart attack within the past 6 months
• You are HIV-positive and on combination HIV treatment
• You are pregnant or breastfeeding
• You are a woman who could become pregnant, or a man whose partner could become pregnant, and you are not willing to use effective contraception during the trial and for at least 6 months after finishing treatment
• You have any other significant health condition that the trial doctor believes would make participation unsafe or unsuitable

Important: Always verify eligibility with the trial site directly before applying.