Phase 3 Hypertension Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older at the time of signing the consent form.
• People who have been diagnosed with high blood pressure (hypertension).
• People who have either never taken blood pressure medication, or who previously took only one type of blood pressure medication at a time and have stopped all blood pressure medication for at least 2 weeks before the screening visit.
• People who are willing to follow all study requirements throughout the trial, including keeping diet and exercise habits stable, attending scheduled study drug injections, and keeping a study diary.

Who may not be able to join:

• People who the trial doctor suspects may be allergic to the study drug or similar medications.
• People who have a history of low blood pressure when standing up (orthostatic hypotension), or whose blood pressure readings at screening meet the criteria for this condition.
• People whose high blood pressure is caused by another underlying medical condition (such as kidney disease, narrowed kidney arteries, narrowing of the main heart artery, hormonal disorders like Cushing's syndrome or pheochromocytoma, polycystic kidney disease, or medication side effects) — sleep apnea-related high blood pressure is an exception (confirm with trial site).
• People who have used a type of heart/blood pressure medication called beta-blockers within the past month before screening.
• People whose body weight has changed by more than 5 kg in the 3 months before screening.
• People who, within the past 6 months, have had a heart attack, unstable chest pain, heart bypass surgery, certain heart procedures, a large or torn blood vessel (aneurysm or dissection), a mini-stroke or stroke, or serious heart rhythm problems; or people who have a history of severe heart failure (classified as NYHA Class III or IV), epilepsy, or fainting episodes — the trial doctor will assess whether participation is appropriate.
• People who have been diagnosed with diabetes, or whose blood sugar test results at screening are above certain levels (HbA1c of 6.5% or higher, fasting blood glucose of 7 mmol/L or higher, or random blood glucose of 11.1 mmol/L or higher).
• People with a history of pancreas or gallbladder problems (such as pancreatitis, acute gallbladder inflammation, or bile duct inflammation), unless they have had their gallbladder removed and the trial doctor approves; or people whose pancreatic enzyme or fat levels in the blood are above certain limits.
• People who have ongoing gut or digestive conditions, or other illnesses that affect how the digestive system works, or who have taken medications affecting digestion, appetite, or nutrient absorption within the 3 months before screening.
• People who have a personal or close family history of a specific type of thyroid cancer (medullary thyroid carcinoma) or a rare hormonal disorder called Multiple Endocrine Neoplasia (MEN) type 2A or 2B.

Important: Always verify eligibility with the trial site directly before applying.