Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults of any gender between 18 and 70 years of age
• People who are willing to sign a consent form and follow all study procedures for the full duration of the trial
• People who have been diagnosed with major depressive disorder (MDD) that is not linked to psychosis, confirmed through a structured diagnostic interview
• People whose depression symptoms score at a moderate level or higher on a standard rating scale (HDRS-17 score of 14 or above)
• People assessed as being at low suicide risk, meaning no active suicidal thoughts in the past month and no suicide attempts, preparatory actions, or significant self-harm in the past two years
• People who are able to understand the risks and potential benefits of joining the study
• People of childbearing potential who have been using highly effective contraception for at least one month before screening and who agree to continue doing so during the study
• People whose depression has not responded well to at least one antidepressant medication in the past or present, confirmed using a standardised treatment history tool (Maudsley Treatment Inventory score of 3 or above)

Who may not be able to join:

• People diagnosed with severe alcohol use disorder in the past 12 months
• People diagnosed with moderate to severe substance use disorder (not including tobacco) in the past 12 months
• People with a lifetime history of bipolar disorder
• People with a diagnosis of schizophrenia or any other psychotic disorder
• People with a history of autism spectrum disorder (as reported by the participant)
• People who have started a new psychiatric medication or had a dose change in the six weeks before screening
• People who have started a new course of psychotherapy in the six weeks before screening
• People who have received any brain stimulation treatment in the six weeks before screening
• People with a history of seizures, other than fever-related seizures in childhood or seizures caused by electroconvulsive therapy (ECT)
• People with neurological conditions that the investigator considers would increase risk or affect study results, such as dementia, stroke, Parkinson's disease, multiple sclerosis, significant traumatic brain injury, a ruptured brain aneurysm, or previous radiation to the brain (confirm with trial site)
• People whose depression previously did not respond to ECT or transcranial magnetic stimulation (TMS)
• People who have had prior brain surgery or have brain implants
• People with a personal or family history of epilepsy
• People with a history of fainting spells or loss of consciousness
• People with metal in the brain, skull, or elsewhere in the body
• People with an implanted medical device that uses electricity, or any implant in the head or neck area, or implants located within 30 centimetres of where the TMS device would be placed
• People who are currently pregnant or breastfeeding
• People currently enrolled in another clinical trial for depression
• People with an unstable medical condition that the investigator believes would increase risk or prevent full participation in the study
• People who are not able to communicate in English

Important: Always verify eligibility with the trial site directly before applying.