Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between the ages of 18 and 60 years (both men and women)
• People who experience episodes of stress or situational anxiety at least once a week
• People who rate their typical anxiety at 40 or above on a 0–100 scale, where 0 means "not stressed or anxious" and 100 means "extremely stressed or anxious"
• People who score 20 or higher on the Positive Reactivity section of a specific emotional reactivity questionnaire called the PERS-S
• People who are able to complete surveys using an online digital platform called Alethios
• People who are only taking well-established, stable doses of prescription or non-prescription medications that are not used to treat anxiety disorders
• People who are in generally good health, based on their own reported medical history and the assessment of the lead researcher
• Women who could become pregnant must agree to use an approved form of birth control during the study (accepted methods include hormonal options such as the pill, implant, injection, ring, or patch; barrier methods such as a condom or diaphragm used with spermicide; or an intrauterine device/IUD)
• People who agree not to use cannabis for the entire duration of the study
• People who agree to keep their usual diet and avoid supplements or herbal products associated with calming effects — such as ashwagandha, L-theanine, or St. John's Wort — for the full study period
• People who are fully informed about the study procedures and agree to take part
• People who are willing to sign an electronic informed consent form in line with relevant research protection regulations

Who may not be able to join:

• People who score above 9 on a depression questionnaire called the PHQ-9, or who give any response other than zero to question 9 of that questionnaire (which relates to thoughts of self-harm)
• People who score above 24 on an anxiety assessment called the Hamilton Anxiety Scale (HAM-A)
• People with a history of severe psychiatric or medical conditions that could interfere with taking part in the study
• People who drink more than 14 alcoholic drinks per week
• People who use cannabis regularly, meaning two or more times per week over the past six weeks
• People with a history of drug misuse or dependence within the past six months
• People whose medication for any health condition has changed in the past three months
• People who are currently taking any prescription medication for anxiety
• People who have received a diagnosis of a mental health condition within the past three months
• People with unstable medical conditions (confirm with trial site)
• People with a known sensitivity or allergic reaction to the study product
• People who are pregnant, planning to become pregnant, or currently breastfeeding
• People who are unable to complete the digital/online requirements of the study
• People who have taken part in another clinical trial within the 30 days before joining this study

Important: Always verify eligibility with the trial site directly before applying.