Phase 2 Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a major depressive episode as part of unipolar major depressive disorder, according to standard diagnostic guidelines (DSM-5).
• People whose depression has not improved after at least one antidepressant medication trial that meets a specific level of adequacy, as measured by a clinical assessment tool called the ATHF-SF (confirm with trial site).
• People whose depression is rated as moderate to severe, based on a score above 19 on a standard depression rating scale called the MADRS.
• People who have not started a new antidepressant or increased their current antidepressant dose in the four weeks before the screening visit.
• People who are able to understand the trial and give their informed consent to participate.

Who may not be able to join:

• People who are unable to give informed consent.
• People who have a medical condition that is currently unstable.
• People who have a neurological condition, or a personal history of seizures or epilepsy.
• People who are currently showing suicidal behaviour, as measured by a clinical assessment tool called the Columbia Suicide Severity Rating Scale.
• People who are pregnant or breastfeeding.
• People who have any psychotic disorder, or who are currently experiencing psychotic symptoms.
• People who have metal implants in the skull or brain, or any other medical device or condition that the trial site considers unsafe for TMS (a type of brain stimulation treatment used in this trial).
• People for whom MRI scanning is not considered safe or suitable.

Important: Always verify eligibility with the trial site directly before applying.