Phase 1 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older, of any gender.
• People who are expected to live for more than 12 weeks.
• People who are reasonably active or able to care for themselves, based on a standard cancer performance scale scored 0 to 2 (confirm with trial site).
• People who have a confirmed diagnosis of active multiple myeloma, as defined by international myeloma guidelines.
• People who have previously had a stem cell transplant, or who have been assessed as not suitable for a stem cell transplant.
• People who have already received at least three types of myeloma treatment — specifically, an immunomodulatory drug, a proteasome inhibitor, and an anti-CD38 treatment — and whose myeloma has stopped responding to, or who could not tolerate, standard available treatments.
• People whose myeloma can be measured through standard testing (with some flexibility in the dose-escalation part of the trial for those with a form of myeloma that produces little or no detectable protein).
• People whose heart, liver, kidneys, and other organs are functioning at a level that meets the trial's health requirements (confirm specific thresholds with trial site).

Who may not be able to join:

• People whose myeloma has spread to the central nervous system (brain or spinal cord).
• People who have plasma cell leukaemia.
• People with a history of heart failure.
• People who have had a stem cell transplant (either using their own cells or a donor's cells) within the 12 weeks before the trial starts, or who are planning to have a stem cell transplant using their own cells.
• People who have had significant graft-versus-host disease within the 12 months before the trial starts, following a donor stem cell transplant.
• People who have received radiotherapy within 21 days before the trial starts.
• People with a history of another active cancer.
• People with a known HIV infection.
• People who currently have an active infection requiring treatment with antibiotics, antivirals, or similar medicines.
• People with an active hepatitis B or hepatitis C infection.
• People with a currently active liver or bile duct disease.
• People who are pregnant or breastfeeding.
• People who currently have pneumonia or inflamed lungs causing symptoms.

Important: Always verify eligibility with the trial site directly before applying.