Phase 2 Peripheral Neuropathy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with breast cancer that is hormone receptor-positive (HR+) and HER2-negative, confirmed by a lab test on tissue.
• Your cancer has spread or come back in a way that cannot be treated with surgery or radiation to try to cure it.
• You have already received at least one previous treatment for your cancer (such as a drug or therapy).
• You have at least one area of cancer that can be measured or tracked on scans.
• You are generally able to carry out daily activities with little or no limitation (confirm with trial site regarding the specific fitness level required).
• You are female, not pregnant, and not breastfeeding — and you are either past menopause, have had a procedure to prevent pregnancy, or agree to use effective birth control during the trial.

Who may not be able to join:

• Your breast cancer is classified as "triple-negative" breast cancer.
• Your cancer has spread to the brain or spinal cord, unless that was already treated, and you have not needed steroid medications for it for at least 4 weeks before starting this trial.
• You have had another type of cancer in the past 2 years, with some exceptions such as certain skin cancers or fully removed early-stage cancers (confirm with trial site for your specific situation).
• You have a feeding tube into your stomach, a condition that affects how your body absorbs food or medication, a blockage in your bowel, or any other issue that might affect how the study drug is absorbed.
• You have a significant heart or cardiovascular condition (confirm with trial site for specifics).
• You have an active infection that is not under control.
• You are currently taking part in another clinical trial that involves a treatment.
• You have had radiation therapy within the last 21 days before starting this trial.
• You have previously been treated with certain targeted drugs that affect specific cell-signalling pathways (known as PI3K, AKT, mTORC1/2, or dual PI3K/mTOR inhibitors — confirm with trial site if unsure whether your past treatments apply).
• You are currently taking, or need to take, certain medications that strongly affect how the liver processes drugs (known as strong CYP3A4 or CYP1A2 inhibitors or inducers — confirm with trial site regarding your current medications).
• Your heart's electrical activity shows a specific irregularity on an ECG called a prolonged QTc interval above a certain level (confirm with trial site for details).
• You have Type 1 or Type 2 diabetes and use insulin to manage it.

Important: Always verify eligibility with the trial site directly before applying.