Early Phase 1 Depression and Anxiety Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are medically able to safely receive TMS (a type of brain stimulation) and the study medications.
• People whose medication routine has been stable for at least one month before the study and who are able to keep it stable throughout the study.
• People who are not currently receiving TMS, ECT (electroconvulsive therapy), or ketamine treatment.
• People who do not have active safety concerns related to suicidal thoughts or behaviours.
• People with moderate to severe Major Depressive Disorder, as measured by a standard depression questionnaire.

Who may not be able to join:

• People with a history of seizures or epilepsy.
• People with a history of any condition, injury, or abnormality affecting the inside of the skull or brain.
• People with a history of traumatic brain injury that involved loss of consciousness lasting more than 15 minutes.
• People who show signs of increased pressure inside the skull.
• People with a significant neurological condition, such as a recent stroke, brain tumour, or a degenerative brain disease (confirm with trial site for full list).
• People with serious medical conditions that could become dangerous if a seizure were to occur, such as certain heart or breathing conditions (confirm with trial site for full list).
• People with severe migraines that may make it difficult to tolerate the treatment.
• People who are unable to tolerate an MRI scan.
• People who are pregnant.
• People with a known allergic reaction to any of the following study drugs: d-cycloserine, baclofen, memantine, or lorazepam.

Important: Always verify eligibility with the trial site directly before applying.