Phase 1 Multiple Sclerosis Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- Adults between 18 and 65 years of age (inclusive).
- People of any gender, including male, female, and non-binary.
- People who have been diagnosed with relapsing-remitting or primary-progressive multiple sclerosis, confirmed by a study neurologist and medical records, according to standard diagnostic criteria.
- People whose level of physical disability from MS falls below a certain threshold on a standard scale used by neurologists (Expanded Disability Status Scale score below 7).
- People who experience significant fatigue, as measured by a standard fatigue questionnaire (Fatigue Severity Scale score of 4 or above).
- People with moderate to severe major depression, confirmed by a score of 18 or above on a standard depression rating scale (Hamilton Depression Rating Scale, 17-item version).
- People who have not had enough benefit from at least one antidepressant medication or one course of talk therapy.
- People whose MS treatment (immunotherapy) has been stable for at least 3 months, and whose other medications have been stable for at least 4 weeks.
- People who have no medical reasons preventing them from safely undergoing TMS (a type of brain stimulation) or MRI scans.
- People who are able to give written consent to participate, and who are able to follow the study requirements.
- People who are able to stick to the treatment schedule.
- People who pass a standard safety screening questionnaire related to TMS treatment.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who have any health condition or physical issue that, in the opinion of the study team, may interfere with their ability to complete the study.
- People who have any health condition or physical issue that, in the opinion of the study team, may put their safety at risk or affect the reliability of the study results.
- People who have a history of seizures.
- People who have any metal implants in the skull (with limited exceptions for very thin titanium skull plates or dental fillings) or certain medical devices such as a pacemaker, deep brain stimulator, medication pump, or cochlear implant.
- People who have had previous skull surgery that left an opening large enough to meet a specific size threshold described in the trial criteria (confirm with trial site).
- People who have a primary psychiatric diagnosis (meaning a mental health condition considered to be their main diagnosis, rather than related to MS).
- People who are considered to be at significant risk of harming themselves or others.
- People who have had a substance use disorder or alcohol use disorder within the past three months.
- People currently in psychotherapy whose treatment has not been stable for at least three months, or where changes to the frequency or focus of sessions are expected during the study.
- People who are currently pregnant, breastfeeding, or who plan to become pregnant during the study.
- People who are currently experiencing active thoughts of suicide, as measured by a specific score on a standard rating scale (a score of 4 or above on item 10 of the MADRS scale).
- People who have previously tried electroconvulsive therapy (ECT) during their current episode of depression without benefit (note: ECT received during a previous episode does not affect eligibility).
- People who have any significant neurological condition other than MS, including but not limited to: conditions associated with increased pressure in the brain, a growth or lesion in the brain, a history of epilepsy, a brain aneurysm, Parkinson's disease, Huntington's disease, or a serious head injury involving loss of consciousness for 5 minutes or more.
- People who have a major unstable medical illness at the time of the study.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If you need support right now
This page includes language about suicide and self-harm, because that is how the trial's eligibility criteria are written. If reading it has been hard, you do not have to keep going. The services below are free, confidential, and answered by people trained for exactly this.
If you or someone else is in immediate danger, call 000.
- Lifeline — 24/7 crisis support: 13 11 14
- Suicide Call Back Service — 24/7 counselling: 1300 659 467
- 13YARN — 24/7, for Aboriginal and Torres Strait Islander people: 13 92 76
- Beyond Blue — 24/7 mental health support: 1300 22 4636
- Emergency: 000
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention. If you are in immediate danger, call your local emergency number.
Voxsanity is not a crisis service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Principal Investigator: Adrianna Giuffre, PhD., Cumming School of Medicine, University of Calgary
Phone: 4039887901
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Presence of demyelinating lesions within the TMS-induced electric field and downstream projections (Safety); Clinical Global Impression-Severity and -Improvement scales (CGI-S, CGI-I); Montgomery-Åsberg Depression Rating Scale (MADRS); 17-item Hamilton Rating Scale for Depression (HAM-D-17); Columbia-Suicide Severity Rating Scale (C-SSRS).
Can't join this trial?
Data last synced from ClinicalTrials.gov: 21 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.