Phase 2 Lung Cancer Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- Adults aged 18 to 75 years, of any gender.
- People with a confirmed diagnosis of non-small cell lung cancer (a type of lung cancer) that has reached an advanced stage (stage IV), who have already received at least one round of standard treatment (including platinum-based chemotherapy, with or without immunotherapy) and whose cancer has continued to grow or spread during or after that treatment.
- People whose cancer has tested positive for a specific gene change called a KRAS mutation.
- People who are in good general health and able to carry out daily activities, as measured by a standard medical scoring system (ECOG score of 0 or 1).
- People who are expected to live for at least 3 more months.
- People who have at least one measurable tumour in the brain, as assessed using standard medical imaging guidelines (RECIST v1.1).
- People whose organs (such as kidneys, liver, and blood cells) are functioning well enough, as confirmed by tests done within 7 days before joining.
- People who have recovered from most side effects of previous cancer treatments, with only mild or no ongoing effects remaining (confirm with trial site for specific details).
- People who are willing to avoid too much sun exposure and to use sunscreen when going outdoors.
- People who are willing to use contraception as required during the trial.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who have previously been treated with certain types of medicines, including MEK inhibitors, anlotinib, or similar drugs that target blood vessel growth (such as cabozantinib, sorafenib, or apatinib).
- People who have had major surgery within the past 28 days, minor surgery within the past 14 days, or who are expected to need major surgery during the trial.
- People who have received systemic cancer treatments (such as chemotherapy, targeted therapy, or immunotherapy) within the past 28 days, or within 5 half-lives of the drug used — whichever is the shorter timeframe.
- People who have used traditional Chinese medicine or related herbal preparations with anti-tumour effects within 7 days before starting the trial.
- People who have had full-dose (radical) radiotherapy within the past 28 days (palliative radiotherapy may be acceptable if it was completed at least 14 days before the trial start — confirm with trial site).
- People who have received a live or live-attenuated vaccine within the past 28 days, or any other vaccine (such as an inactivated COVID-19 vaccine) within the past 14 days.
- People who have had an organ transplant from another person, a stem cell transplant from another person, or their own stem cell transplant within the past 3 months.
- People with brain metastases that are currently active, or cancer that has spread to the brainstem, the lining of the brain, the spinal cord, or is pressing on the spinal cord.
- People diagnosed with small cell lung cancer, or a mixed type of lung cancer that includes small cell, or a specific type of squamous cell lung cancer with a cavity (hole) in the centre of the tumour.
- People who have already received four or more rounds of systemic cancer treatment.
- People with an active autoimmune disease (where the immune system attacks the body) that has required ongoing systemic treatment within the past 2 years, with some exceptions (confirm with trial site).
- People with an active infection that has required systemic treatment within the 2 weeks before starting the trial.
- People with high blood pressure that is not well controlled.
- People who have difficulty swallowing, active digestive system disease, problems absorbing nutrients, or any condition that could prevent the study drug from being properly absorbed.
- People with certain eye conditions, including retinal vein blockage, detachment of part of the retina, uncontrolled glaucoma, or other eye problems that could interfere with monitoring for eye-related side effects.
- People with current or previous scarring of the lung tissue (pulmonary fibrosis or pneumonitis), active lung inflammation, a history of a hole forming between the airway and another structure (tracheal fistula), or who need ongoing oxygen due to severe breathing difficulties.
- People with active hepatitis B or hepatitis C, known HIV/AIDS, active tuberculosis, or active syphilis.
- People whose tumour has grown into major blood vessels, the heart, the sac around the heart, the windpipe, or the food pipe, or who are at high risk of developing an abnormal opening between the food pipe and the airway or chest cavity.
- People who have had significant coughing up of blood within the past month, or who have a significant bleeding problem, a clotting disorder, or a history of serious blood clots (grade 3 or higher).
- People with troublesome fluid build-up around the lungs, in the abdomen, or around the heart that keeps coming back and needs frequent draining.
- People who have been diagnosed with another type of cancer within the past 5 years.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
If this is close to home
This page includes language about advanced illness, prognosis, or palliative care, because that is how the trial's eligibility criteria are written. Seeing it set out plainly can land hard, whether it is about you or about someone you are caring for. You do not have to be at a crisis point to talk to someone.
- Griefline — grief and loss counselling, 9am to 6pm weekdays and midday to 6pm weekends (AEST/AEDT): 1300 845 745
- Carer Gateway — practical and emotional support if you are caring for someone, 8am to 5pm weekdays: 1800 422 737
- Canteen — for 12 to 25 year olds affected by cancer, their own or a family member's: 1800 945 215
- Palliative Care Australia — directory of palliative care services near you: palliativecare.org.au
- Lifeline — 24/7, for any kind of distress, at any hour the services above are closed: 13 11 14
Palliative care is not the same as giving up on treatment, and it is not only for the last weeks of life. It is symptom and comfort care that can run alongside active treatment, including a clinical trial.
Outside Australia? The numbers above are Australian and will not work from overseas. Find a Helpline is a free directory of support and crisis lines in over 130 countries, run by ThroughLine with the International Association for Suicide Prevention.
Voxsanity is not a counselling or medical service, and nothing on this page is medical advice. More Australian services are listed on our support lines page.
Contact this trial
Phone: +86 13817833343
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
the objective response rate (ORR) per RECIST v1.1
Can't join this trial?
Data last synced from ClinicalTrials.gov: 17 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.