Phase 1 Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 30 and 70 years old
• You have been formally diagnosed with Parkinson's disease using recognised medical diagnostic criteria
• You have had Parkinson's disease for more than 5 years
• Your Parkinson's is at a moderate stage (Hoehn and Yahr stage 2 or 3 when your medication is not working, known as the "OFF" period) (confirm with trial site)
• You are currently taking Parkinson's medication by mouth, but your symptoms are not well enough controlled, or you are having unwanted side effects from your current treatment
• You have no history of, or only mild, involuntary movements caused by levodopa medication (confirm with trial site)
• Your symptoms respond meaningfully when you take a proper dose of levodopa, as assessed by the trial doctor
• Your blood test results meet specific requirements for white blood cells, platelets, liver function, and kidney function (confirm with trial site)
• You are willing and able to give informed consent to take part

Who may not be able to join:

• You have a condition that affects how your immune system works
• A brain MRI scan has shown brain injuries such as shrinkage, stroke, trauma, or abnormal blood vessels
• A specific brain scan (DaT SPECT) shows unusual results in a particular area of the brain (confirm with trial site)
• Any other abnormal findings are found on your brain MRI scan
• You test positive for a gene mutation called GBA
• You have been diagnosed with dementia, shown by a memory and thinking test score below 24 (MoCA test)
• You have a condition affecting blood clotting, or you are at high risk of bleeding
• You test positive for certain viruses or active infections, including hepatitis B, hepatitis C, HIV, HTLV, syphilis, CMV, chickenpox virus, Epstein-Barr virus, or COVID-19
• You are unable to have an MRI scan, for example because you have metal implants, a pacemaker, an MRI-incompatible artificial heart valve, severe claustrophobia, or your body weight is outside the range the MRI machine can accommodate
• You have a known allergy or medical reason that prevents you from taking the study medications: Tacrolimus, Prednisolone, Basiliximab, Cotrimoxazole, or MRI contrast dye
• You are currently receiving or have received another type of cell transplant, including stem cell treatments
• You have or have had cancer, epilepsy, or bleeding in the brain alongside your Parkinson's disease
• You have an uncontrolled or treatment-resistant psychiatric condition such as severe depression, bipolar disorder, or schizophrenia, confirmed by a psychiatrist
• A psychiatrist has determined that you have an intellectual disability that prevents you from fully understanding what the study involves
• You have previously had brain surgery for Parkinson's, such as pallidotomy, thalamotomy, or deep brain stimulation (DBS)
• You are considered too high a risk for surgery due to significant heart, lung, or other serious health conditions
• In the three months before joining, you have taken immunosuppressant drugs, antipsychotic medication, anti-seizure drugs, or blood thinners (unless safely stopped or adjusted); or in the six months before joining, you have received botulinum toxin injections, phenol injections, or similar treatments for muscle spasms
• You have previously used a medication called Apomorphine for Parkinson's
• You have a history of long-term heavy alcohol use or illegal drug use
• You are pregnant, breastfeeding, or unwilling to use contraception during the study
• The trial researchers have any other safety concerns about your participation (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.