Phase 2 Myeloma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 80 years
• People who have been newly diagnosed with multiple myeloma that is causing symptoms, based on internationally recognised diagnostic criteria
• People who have received at most one cycle of treatment for multiple myeloma before enrolling, as long as that treatment did not include immunotherapy
• People whose myeloma can be measured through at least one of the following: a specific abnormal protein detected in the blood at a certain level; an abnormal protein detected in urine over a 24-hour collection; or an abnormal balance of certain protein fragments in the blood (confirm with trial site for exact thresholds)
• People whose myeloma has caused kidney damage of a specific type — where the kidneys are being harmed by protein casts blocking the kidney tubes — with kidney function below a certain threshold as measured by a standard formula; a kidney biopsy may be required to confirm this in some cases (confirm with trial site)
• People whose general physical health and ability to carry out daily activities falls within an acceptable range on a standard medical scoring scale (a score of 0, 1, or 2 on the ECOG scale)
• People whose blood cell counts, liver function, and blood clotting results meet the minimum levels required by the trial (confirm with trial site for specific values)
• People who do not have another active cancer, or whose other cancer is not expected to affect survival within the next 12 months
• People who are willing to participate, able to follow the study requirements, and able to provide signed consent

Who may not be able to join:

• People diagnosed with related but distinct conditions such as smoldering myeloma, MGUS, Waldenström's macroglobulinemia, POEMS syndrome, amyloidosis, or secondary plasma cell leukaemia
• People whose myeloma or cancer has spread to the brain or the fluid surrounding the brain and spine
• People with serious or poorly controlled heart conditions, including unstable chest pain, heart failure with symptoms, a heart attack within the past 6 months, severe irregular heartbeat, or other heart or stroke-related conditions the trial doctor considers unsuitable
• People with active infections, including HIV, active hepatitis B, active hepatitis C, active or latent syphilis, active tuberculosis detected in the past 3 months or during screening, or other active infections the trial doctor considers unsuitable
• People with another cancer occurring at the same time, or with serious other health conditions that could put their safety at risk or interfere with completing the trial
• People who are pregnant or breastfeeding
• People who have previously had a severe allergic reaction (grade 3 or higher) to any ingredient in the study medications
• People who are unwilling or unable to sign the consent form
• People who, in the trial doctor's judgement, are unsuitable for any other reason

Important: Always verify eligibility with the trial site directly before applying.