Phase 2 Colorectal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old (any gender)
• You have been diagnosed with Stage II or Stage III rectal cancer, with no spread to distant parts of the body, as confirmed by MRI or internal ultrasound scan
• Your tumor is located in the lower part of the rectum, no more than 10 cm from the opening of the back passage, confirmed by a camera test or physical examination
• Your cancer has been confirmed by a tissue sample (biopsy) to be a specific type called rectal adenocarcinoma
• You are generally able to carry out daily activities with little or no restriction (confirm with trial site)
• Your blood counts are within acceptable ranges, including enough red blood cells, white blood cells, and platelets
• Your kidney function blood tests are within the normal range
• Your liver function blood tests are within acceptable ranges
• Your urine protein test is normal, and your blood clotting is normal
• You have no known allergy to platinum-based chemotherapy drugs (a type of cancer medication)
• You have not had surgery (other than a colostomy bag procedure), chemotherapy, or any other cancer treatment since your diagnosis
• You have not previously had radiotherapy to the area of the body that would be treated in this trial
• You are willing and able to sign a consent form agreeing to take part

Who may not be able to join:

• You have previously been treated with certain types of immunotherapy drugs (including anti-PD-1, anti-PD-L1, or anti-CTLA-4 treatments, or other experimental immune-based therapies)
• You have a serious autoimmune condition, such as Crohn's disease, ulcerative colitis, rheumatoid arthritis, lupus, or a similar immune system disorder
• You have a lung condition causing symptoms, or currently have an active lung infection or inflammation
• You have, or are at risk of, a bowel perforation (a hole or tear in the intestine), for example due to a bowel blockage or abdominal abscess
• You have a history of another cancer, unless it was a type of non-melanoma skin cancer or a very early-stage cervical change that has been fully treated and cured
• You currently have an active serious infection, heart failure, have had a heart attack in the last 6 months, or have unstable heart problems
• You have other health conditions or test results that the trial doctor believes could interfere with the study or put you at greater risk
• You are currently pregnant or breastfeeding
• You have a condition that weakens your immune system, including HIV, or have previously had an organ transplant or stem cell transplant
• You have an active hepatitis B infection with a high virus level, active hepatitis C infection, or active tuberculosis
• You have received a cancer vaccine or certain other vaccines within 4 weeks before starting treatment (note: standard injected flu vaccines are generally allowed, but nasal spray flu vaccines are not — confirm with trial site)
• You are currently taking other immune-affecting medications, chemotherapy, drugs as part of another clinical trial, or long-term steroid treatment
• You have a mental health condition, substance misuse issue, or other personal circumstances that a doctor believes may make it difficult for you to follow the trial requirements
• You have a known allergy or medical reason why you cannot take the drugs used in this trial

Important: Always verify eligibility with the trial site directly before applying.