Depression and Anxiety Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People aged between 18 and 65 years
- People who have been diagnosed with Major Depressive Disorder (a form of clinical depression) based on standard diagnostic guidelines known as DSM-5
- People whose depression has not improved enough after trying at least one course of antidepressant medication at an appropriate dose and duration
- People whose depression symptoms score at a certain level of severity on a standard rating scale called the Hamilton Depression Rating Scale (confirm with trial site for exact scoring details)
- People who have been taking the same antidepressant at a stable dose for at least 4 weeks before joining the study
- People who are able to read, understand, and sign a written consent form agreeing to take part
Who may not be able to join:
- People with a history of bipolar disorder, schizophrenia, schizoaffective disorder, or psychotic depression
- People who currently have a problem with alcohol or drug misuse or dependence
- People with a neurological condition that affects how the brain works, such as epilepsy, multiple sclerosis, dementia, or Parkinson's disease
- People who have ever had an epileptic seizure
- People who have had a serious head injury in the past
- People who have any metal implants in the head or neck area
- People who have a cochlear implant (a device implanted in the ear to help with hearing)
- People who have a cardiac pacemaker or any other implanted electronic medical device
- People who have previously had deep brain stimulation or vagus nerve stimulation treatment
- People who have had any previous brain surgery or neurosurgical procedure
- People who are currently pregnant or breastfeeding
- People taking medications that may significantly affect certain biological markers in the body, such as corticosteroids or immune-modifying drugs (confirm specific medications with trial site)
- People with hormonal or gland disorders that affect the body's stress response system, such as Cushing's syndrome, Addison's disease, or thyroid conditions
- People with autoimmune diseases, such as lupus, rheumatoid arthritis, or Hashimoto's thyroiditis
- People who have recently had surgery or who currently have an active infection
- People who are currently in an active suicidal crisis, experiencing severe agitation, or who would not be able to follow the study procedures
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Cana Aksoy Poyraz, Prof. Dr., Istanbul University - Cerrahpasa
Phone: +90 506 303 10 68
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in Hamilton Depression Rating Scale (HAM-D) Score
Can't join this trial?
Data last synced from ClinicalTrials.gov: 19 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.