Early Phase 1 Parkinson's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 60 years old
• People who are generally in good health, as confirmed by a physical check-up, blood tests, heart trace (ECG), and review of medical history at the screening visit
• People who are able to follow all study procedures as required
• People who are able to read, understand, and sign a consent form agreeing to take part
• Women who are not able to become pregnant — either because they have gone through menopause (no periods for at least 12 months) or have had a surgical procedure such as removal of the ovaries, fallopian tube ligation, or hysterectomy
• Women who are able to become pregnant but are using a highly effective form of contraception (such as the oral contraceptive pill taken for at least 3 months beforehand, an IUD fitted at least 2 months beforehand, or a barrier method such as a diaphragm or condom with spermicide) starting at least 14 days before the study injection and for at least 24 hours after — note that periodic abstinence methods (such as calendar or ovulation tracking) are not accepted under the trial criteria
• Men whose female partners could become pregnant must use adequate contraception and must not donate sperm for 90 days after the study injection

Who may not be able to join:

• People who have taken prescription medications or herbal supplements within 4 weeks before the first dose, or over-the-counter medications or dietary supplements (including vitamins) within 2 weeks before the first dose (limited use of paracetamol/acetaminophen may be acceptable — confirm with trial site)
• People who have taken part in another clinical trial within 4 weeks before the first dose, or within 5 half-lives of the investigational drug used in that trial if that period is longer than 4 weeks
• People who have been exposed to more than 50 millisieverts (mSv) of radiation in the past year — for example, through work or radiation treatment
• People who have donated or lost 400 ml or more of blood within 8 weeks before the first dose (or longer if required by local rules)
• People who have a current or past significant health condition affecting the heart, lungs, liver, kidneys, digestive system, hormonal system, or nervous system that the study doctor believes could affect how the study drug is processed by the body, or that could put the person at risk
• People with abnormal results on blood or urine laboratory tests that the study doctor considers clinically significant
• People with significant abnormal findings on a heart trace (ECG)
• People with a history of immune system diseases, or a positive test result for HIV
• People who test positive for Hepatitis B or Hepatitis C
• People with a history of drug or alcohol misuse in the 12 months before screening, or whose screening tests suggest current misuse
• People who have used tobacco products within 3 months before screening (confirmed by a urine test)
• Women who have a positive pregnancy test result
• Women who are currently breastfeeding or lactating

Important: Always verify eligibility with the trial site directly before applying.