Phase 1 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be willing and able to sign a consent form before taking part in the study.
• You must be 18 years of age or older.
• You must be well enough to carry out some daily activities — not completely disabled by your illness (confirm with trial site regarding specific fitness level required).
• You must have been diagnosed with one of the following cancers — advanced or metastatic pancreatic cancer, non-small cell lung cancer, a specific type of hormone-sensitive breast cancer (HR+/HER2-), triple-negative breast cancer, colorectal cancer, or soft tissue sarcoma — at any stage of prior treatment.
• You must have at least one tumour that can be measured on a scan (MRI or CT).
• You must have a stored tissue sample from your tumour available at the time of screening.

Who may not be able to join:

• Your blood test results must be within acceptable ranges — including kidney function, liver function, red and white blood cell counts, and platelet levels (confirm with trial site for specific values).
• You have a urinary tract blockage or bladder control problem that cannot be managed (for example, with a stent).
• You have a known allergy to either of the imaging agents used in this study (68Ga-DFC413 or 68Ga-NNS309) or their ingredients.
• You have a serious infection that is not under control at the time of joining the study.
• You have had major surgery or a major invasive procedure within 4 weeks before receiving the imaging agents, or between the two imaging scans.
• You have had radiation therapy within 2 weeks before receiving the imaging agents, or between the two imaging scans.
• Your cancer treatment has changed within 2 weeks before receiving the imaging agents, or between the two imaging scans.
• You have received an X-ray contrast dye within 48 hours before receiving the imaging agents.
• You have recently started or increased the dose of certain medicines, including steroids or immune-modifying drugs, within 2 weeks before the imaging agents are given (confirm with trial site for full list).
• You have another cancer that is currently growing or being actively treated.
• You are unable to complete the required scans for any reason — for example, severe claustrophobia or being unable to lie still for the duration of the scan.
• You are currently experiencing significant side effects from previous cancer treatment (with some exceptions for certain nerve-related side effects and hair loss — confirm with trial site).
• You have any other medical condition that, in the opinion of the doctor running the trial, makes it unsafe or unsuitable for you to participate.
• You are currently pregnant.
• You are currently breastfeeding — however, women who do not breastfeed for 12 hours after receiving the imaging agents, and who express and discard breast milk during that time, may still be eligible.
• You are a woman who could become pregnant and are not using a highly effective method of contraception for at least 12 hours after receiving the imaging agents (confirm with trial site for accepted methods).
• You are a sexually active male who is unwilling to use a condom during sex for at least 12 hours after receiving the imaging agents, or who is unwilling to avoid donating sperm during that period.

Important: Always verify eligibility with the trial site directly before applying.