Phase 3 Pancreatic Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are willing to take part voluntarily and sign a consent form agreeing to participate in the study
• People aged 18 to 75 years old, of any gender
• People who have been diagnosed with a specific type of pancreatic cancer called pancreatic ductal adenocarcinoma, confirmed through a tissue or cell sample, with no sign that the cancer has spread to distant parts of the body
• People who had chemotherapy before surgery (up to 4 cycles) and, after surgery, had at least one higher-risk finding — such as cancer cells left at or near the surgical edges (R1/R2 resection), cancer spread to nearby lymph nodes, cancer growing into nerves or blood vessels, a tumour larger than 4cm, or a tumour that looked aggressive under the microscope (poorly differentiated)
• People whose scans (CT or MRI) after surgery showed no signs of the cancer getting worse
• People whose blood and organ function meets certain minimum levels, including healthy enough counts for white blood cells, platelets, and red blood cells, as well as acceptable liver and kidney function (confirm specific values with trial site)
• People with a good general level of physical functioning, rated 0 or 1 on a standard medical scale (meaning mostly active and able to carry out daily activities with little or no restriction)
• People whose doctors expect them to survive at least 3 months after surgery
• Women who are not pregnant, do not plan to become pregnant, and people of childbearing age who agree to use medically approved contraception during the trial

Who may not be able to join:

• People who received radiotherapy, palliative chemotherapy, targeted therapy, or immunotherapy for their pancreatic cancer before surgery
• People with serious ongoing health conditions, including active infections needing medication, uncontrolled diabetes or high blood pressure, severe heart failure, unstable chest pain, a heart attack within the past 3 months, fluid build-up around the lungs or abdomen, severe liver or portal vein problems, stomach outlet blockage, breathing difficulties requiring oxygen, or significant neurological or mental health conditions
• People with a history of another cancer (though cured skin basal cell carcinoma and a very early-stage cervical cancer diagnosis may not be disqualifying — confirm with trial site)
• People with bleeding problems or conditions that affect how their blood clots
• People who experienced serious complications after surgery — such as bleeding, pancreatic leakage, stomach emptying problems, abdominal infection, or bile leakage — that would prevent them from starting treatment within 12 weeks of the operation
• People who are known to be allergic to any of the medications used in this trial
• People known to be living with HIV or syphilis, or who have active hepatitis B or C
• Women who are pregnant, breastfeeding, or planning to become pregnant during the study, or female partners of male participants who fall into these categories
• People who are unlikely to be able to follow the study's procedures and requirements consistently
• People considered unsuitable for any other reason, as determined by the trial team

Important: Always verify eligibility with the trial site directly before applying.