Phase 1 Mesothelioma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older, of any gender
• People whose doctors estimate they have more than 3 months to live
• People who are largely able to carry out daily activities with little or no restriction (confirm with trial site what this means for a specific situation)
• People who have advanced or metastatic solid tumours that have continued to grow despite standard treatments, or where standard treatments are not suitable — eligible cancer types include triple-negative breast cancer, hormone receptor-positive breast cancer, colon cancer, gastric (stomach) cancer, liver cancer (HCC), non-small cell lung cancer, mesothelioma, pancreatic cancer, hormone-resistant prostate cancer, and soft tissue sarcoma; other cancer types may be considered after discussion with the trial's medical team
• People who have at least one tumour that can be measured using standard imaging methods
• People who have a tumour that can be safely biopsied (a small tissue sample taken for testing)
• People whose blood tests show the heart, liver, kidneys, and bone marrow are functioning adequately
• People who are willing and able to give informed consent to participate
• Women who could become pregnant must have a negative blood pregnancy test before starting and must use effective contraception throughout the trial and for 90 days after the last dose
• Men must use barrier contraception or abstain from sex, and must not donate sperm, during the trial and for 90 days after the last dose
• People with brain metastases (cancer that has spread to the brain) may be eligible if those metastases have been stable for at least 4 weeks following radiotherapy and steroid medication was stopped at least 14 days before joining

Who may not be able to join:

• People with serious, high-risk heart or cardiovascular disease
• People currently receiving other anti-cancer treatments
• People who have had an active infection requiring treatment with antibiotics or antivirals within the 2 weeks before starting the trial
• People with a history of a second, separate cancer (though certain exceptions apply, such as skin cancers or cancers that have been in remission for 2 or more years — confirm with trial site)
• People with active hepatitis B, active hepatitis C, or poorly controlled HIV; people who have had a serious HIV-related infection within the past 12 months (note: people with well-controlled HIV may still be considered — confirm with trial site)
• People who have had significantly reduced lung function within the 6 months before starting the trial
• People who are pregnant or breastfeeding
• People who have recently had radiotherapy, systemic cancer treatment, or participated in another clinical trial without a sufficient gap before joining this trial (confirm with trial site what timeframe applies)
• People who have had major surgery within 4 weeks before starting the trial
• People who are unable to swallow tablets, or who have a condition that affects how the gut absorbs medication
• People with medical or psychiatric conditions that could affect their ability to follow the trial requirements or that could make the results difficult to interpret
• People who still have significant side effects from previous cancer treatments (some exceptions may apply — confirm with trial site)
• People with a clinically significant eye condition affecting the cornea
• People who are unable to avoid certain medications that are not permitted during the trial

Important: Always verify eligibility with the trial site directly before applying.