Rare disease
Atypical Haemolytic Uraemic Syndrome
Clinical trials recruiting in Australia for Atypical Haemolytic Uraemic Syndrome, a rare disease, as the public registries list them.
Also called: Atypical HUS; aHUS; Atypical hemolytic uremic syndrome; Atypical hemolytic-uremic syndrome
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At a glance
3 trials recruiting in Australia
10 trials recruiting overseas
1-9 / 100 000 (Point prevalence, Europe, Validated) prevalence
All ages age of onset
11 October 2026 date last checked
Trials in Australia
This Australian count is likely to be on the low side. It counts the trials this site files under this condition; the registry’s own search is broader and also returns closely related conditions, some of which have their own page here. If you are searching widely, check the registry as well — every trial below links to its own record.
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Recruiting Not a phased study
Study for people with Atypical Haemolytic Uraemic Syndrome
Where- Clinical Trial Site 1, Westmead (NSW) — Recruiting
- Clinical Trial Site 2, Westmead (NSW) — Recruiting
- Clinical Trial Site, Cairns (QLD) — Recruiting
- Clinical Trial Site, Herston (QLD) — Recruiting
- Clinical Trial Site, Woolloongabba (QLD) — Recruiting
- Clinical Trial Site, Adelaide (SA) — Recruiting
- Clinical Trial Site, Heidelberg (VIC) — Recruiting
- Clinical Trial Site, Parkville (VIC) — Recruiting
- Clinical Trial Site, Parkville (VIC) — Recruiting
- Clinical Trial Site, Murdoch (WA) — Recruiting
- Clinical Trial Site, Nedlands (WA) — Active not recruiting
Who can join Age child, adult, older adult. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Alexion Pharmaceuticals, Inc.TimelineStarted 18 March 2013 Today 16 October 2026 Estimated completion 1 January 2031NCT01522183 · Checked 11 October 2026
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Recruiting Not a phased study
Study for people with Atypical Haemolytic Uraemic Syndrome
Where- Online Patient Enrollment System, Sydney — Recruiting
Who can join Age child, adult, older adult. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Sanford HealthTimelineStarted 1 July 2010 Today 16 October 2026 Estimated completion 1 December 2100NCT01793168 · Checked 11 October 2026
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Recruiting Not a phased study
Study for people with Atypical Haemolytic Uraemic Syndrome
WhereNo Australian site on this record is listed as recruiting right now, even though the trial itself is open. Check with the site or the official record before travelling.
- Research Site, Melbourne (VIC) — Not yet recruiting
Who can join Age child, adult, older adult. Sex Female participants only. Healthy volunteers Not accepted.Sponsor Alexion Pharmaceuticals, Inc.TimelineStarted 16 December 2024 Today 16 October 2026 Estimated completion 11 July 2034NCT06312644 · Checked 11 October 2026
Trials overseas
10 trials for this disease are open to new participants outside Australia, as ClinicalTrials.gov listed them on 11 October 2026. Voxsanity does not publish a page for any of them; the searches below reach them at the registry.
These overseas counts are likely too high. They come from the registry’s own search, which expands a condition name to related conditions, so some of the trials counted are for a different disease in the same family.
Search ClinicalTrials.gov Search the WHO registry portal Joining a trial overseas
Trials not shown here
Some Australian trials are registered only on the Australian New Zealand Clinical Trials Registry and are not shown here. Search them at Australian Clinical Trials.
Key facts
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com).
About Atypical Haemolytic Uraemic Syndrome
The text below is reproduced exactly as its source published it. It has not been edited, shortened or rewritten.
Atypical hemolytic-uremic syndrome is a disease that primarily affects kidney function. This condition, which can occur at any age, causes abnormal blood clots (thrombi) to form in small blood vessels in the kidneys. These clots can cause serious medical problems if they restrict or block blood flow. Atypical hemolytic-uremic syndrome is characterized by three major features related to abnormal clotting: hemolytic anemia, thrombocytopenia, and kidney failure. Hemolytic anemia occurs when red blood cells break down (undergo hemolysis) prematurely. In atypical hemolytic-uremic syndrome, red blood cells can break apart as they squeeze past clots within small blood vessels. Anemia results if these cells are destroyed faster than the body can replace them. Anemia can lead to unusually pale skin (pallor), yellowing of the eyes and skin (jaundice), fatigue, shortness of breath, and a rapid heart rate. Thrombocytopenia is a reduced level of circulating platelets, which are cells that normally assist with blood clotting. In people with atypical hemolytic-uremic syndrome, fewer platelets are available in the bloodstream because a large number of platelets are used to make abnormal clots. Thrombocytopenia can cause easy bruising and abnormal bleeding. As a result of clot formation in small blood vessels, people with atypical hemolytic-uremic syndrome experience kidney damage and acute kidney failure that lead to end-stage renal disease (ESRD) in about half of all cases. These life-threatening complications prevent the kidneys from filtering fluids and waste products from the body effectively. Atypical hemolytic-uremic syndrome should be distinguished from a more common condition called typical hemolytic-uremic syndrome. The two disorders have different causes and different signs and symptoms. Unlike the atypical form, the typical form is caused by infection with certain strains of Escherichia coli bacteria that produce toxic substances called Shiga-like toxins. The typical form is characterized by severe diarrhea and most often affects children younger than 10. The typical form is less likely than the atypical form to involve recurrent attacks of kidney damage that lead to ESRD.
US source; availability in Australia may differ.
Source: MedlinePlus Genetics (medlineplus.gov), public domain (U.S. National Library of Medicine). Read the full source.
Sources and dates
- ClinicalTrials.gov – trial records, statuses and site lists
- MedlinePlus – the About text above, reproduced exactly
- Orphanet / Orphadata – prevalence, age of onset, inheritance, genes and alternative names, used under CC BY 4.0
- ClinicalTrials.gov processing date: 16 April 2026.
- This page last checked by Voxsanity: 11 October 2026.
Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.
Not medical advice.
Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.
Orphanet citation
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com). Accessed 20 September 2026.
Atypical Haemolytic Uraemic Syndrome is one of the rare diseases tracked on the Voxsanity rare disease hub, where you can compare it with every other rare condition we follow and filter trials by country.
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