Most hereditary angioedema trials do not say which type they are studying. This page counts those trials, because types 1 and 2 are the same underlying problem — a missing or faulty C1-inhibitor protein — and trials that do not name a type usually enrol both. That is our editorial judgement, not something the trial registry states, so confirm with the trial site that type 2 is included before you rely on it. Trials naming type 1 only, and acquired C1-inhibitor deficiency, which is a different illness, are not counted.
Rare disease
Hereditary Angioedema Type 2
Clinical trials recruiting in Australia for Hereditary Angioedema Type 2, a rare disease, as the public registries list them.
Also called: Familial angioneurotic edema; HAE; Hereditary angioneurotic edema; Hereditary bradykinine-induced angioedema; Hereditary non histamine-induced angioedema; Hereditary angioedema; HANE; C1 inhibitor deficiency; C1 esterase inhibitor deficiency; Hereditary angioneurotic oedema
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At a glance
7 trials recruiting in Australia
21 trials recruiting overseas
1-9 / 100 000 (Point prevalence, Europe, Validated) prevalence
All ages age of onset
11 October 2026 date last checked
Trials in Australia
This Australian count is likely to be on the low side. It counts the trials this site files under this condition; the registry’s own search is broader and also returns closely related conditions, some of which have their own page here. If you are searching widely, check the registry as well — every trial below links to its own record.
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By invitation Phase 3
Phase 3 study for people with Hereditary Angioedema Type 2
WhereNo Australian site on this record is listed as recruiting right now, even though the trial itself is open. Check with the site or the official record before travelling.
- Study site, Campbelltown (NSW) — this site's status is not stated on the record
Who can join Age 12 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Pharvaris Netherlands B.V.TimelineStarted 28 December 2022 Today 16 October 2026 Estimated completion 1 June 2027NCT05396105 · Checked 11 October 2026
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By invitation Not a phased study
Study for people with Hereditary Angioedema Type 2
WhereNo Australian site on this record is listed as recruiting right now, even though the trial itself is open. Check with the site or the official record before travelling.
- Campbelltown Hospital, Campbelltown (NSW) — this site's status is not stated on the record
Who can join Age child, adult, older adult. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Intellia TherapeuticsTimelineStarted 12 April 2024 Today 16 October 2026 Estimated completion 1 April 2040NCT06262399 · Checked 11 October 2026
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By invitation Phase 3
Phase 3 study for people with Hereditary Angioedema Type 2
WhereNo Australian site on this record is listed as recruiting right now, even though the trial itself is open. Check with the site or the official record before travelling.
- Study Site, Box Hill (VIC) — this site's status is not stated on the record
- Study Site, Parkville — this site's status is not stated on the record
- Study Site, Perth — this site's status is not stated on the record
- Study Site, Sydney — this site's status is not stated on the record
Who can join Age 12 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Pharvaris Netherlands B.V.TimelineStarted 1 February 2025 Today 16 October 2026 Estimated completion 1 December 2028NCT06679881 · Checked 11 October 2026
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Recruiting Phase 3
Phase 3 study for people with Hereditary Angioedema Type 2
Where- ADARx Clinical Site, Campbelltown (NSW) — Not yet recruiting
- ADARx Clinical Site, Adelaide (SA) — Recruiting
Who can join Age 18 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor ADARx Pharmaceuticals, Inc.TimelineStarted 28 August 2025 Today 16 October 2026 Estimated completion 30 November 2027NCT06960213 · Checked 11 October 2026
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Recruiting Phase 3
Phase 3 study for people with Hereditary Angioedema Type 2
Where- Study Site, Clayton — Recruiting
Who can join Age 18 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Pharvaris Netherlands B.V.TimelineStarted 16 October 2025 Today 16 October 2026 Estimated completion 1 June 2027NCT07266805 · Checked 11 October 2026
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Recruiting Phase 3
Phase 3 study for people with Hereditary Angioedema Type 2
Where- Ionis Investigative Site, South Brisbane (QLD) — Recruiting
- Ionis Investigative Site, Clayton (VIC) — Recruiting
Who can join Age 2 Years to 11 Years. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor Ionis Pharmaceuticals, Inc.TimelineStarted 21 April 2026 Today 16 October 2026 Estimated completion 1 June 2029NCT07298447 · Checked 11 October 2026
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Recruiting Phase 3
Phase 3 study for people with Hereditary Angioedema Type 2
WhereNo Australian site on this record is listed as recruiting right now, even though the trial itself is open. Check with the site or the official record before travelling.
- ADARx Clinical Site, Adelaide (SA) — Not yet recruiting
Who can join Age 18 Years and over. Sex Anyone, regardless of sex. Healthy volunteers Not accepted.Sponsor ADARx Pharmaceuticals, Inc.TimelineStarted 2 April 2026 Today 16 October 2026 Estimated completion 30 June 2030NCT07428499 · Checked 11 October 2026
Trials overseas
21 trials for this disease are open to new participants outside Australia, as ClinicalTrials.gov listed them on 11 October 2026. Voxsanity does not publish a page for any of them; the searches below reach them at the registry.
These overseas counts are likely too high. They come from the registry’s own search, which expands a condition name to related conditions, so some of the trials counted are for a different disease in the same family.
Search ClinicalTrials.gov Search the WHO registry portal Joining a trial overseas
Trials not shown here
Some Australian trials are registered only on the Australian New Zealand Clinical Trials Registry and are not shown here. Search them at Australian Clinical Trials.
Key facts
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com).
About Hereditary Angioedema Type 2
The text below is reproduced exactly as its source published it. It has not been edited, shortened or rewritten.
Hereditary angioedema is a disorder characterized by recurrent episodes of severe swelling (angioedema). The parts of the body that are most often affected by swelling are the limbs, face, intestinal tract, and airway. Minor trauma or stress may trigger an attack, but swelling often occurs without a known trigger. Episodes involving the intestinal tract cause severe abdominal pain, nausea, and vomiting. Swelling in the airway can restrict breathing and lead to life-threatening obstruction of the airway. About one-third of people with this condition develop a non-itchy rash called erythema marginatum during an attack. Symptoms of hereditary angioedema typically begin in childhood and worsen during puberty. On average, untreated individuals have swelling episodes every 1 to 2 weeks, and most episodes last for about 3 to 4 days. The frequency and duration of attacks vary greatly among people with hereditary angioedema, even among people in the same family. Hereditary angioedema is broadly divided into two types, which are distinguished by levels of a protein called C1 inhibitor (C1-INH) in the blood. These types are known as hereditary angioedema due to C1-INH deficiency and hereditary angioedema with normal C1-INH. Hereditary angioedema due to C1-INH deficiency is further divided into two types: type I occurs when C1-INH levels are low, and type II occurs when the C1-INH protein is not functioning correctly. The different types of hereditary angioedema have similar signs and symptoms.
US source; availability in Australia may differ.
Source: MedlinePlus Genetics (medlineplus.gov), public domain (U.S. National Library of Medicine). Read the full source.
Sources and dates
- ClinicalTrials.gov – trial records, statuses and site lists
- MedlinePlus – the About text above, reproduced exactly
- Orphanet / Orphadata – prevalence, age of onset, inheritance, genes and alternative names, used under CC BY 4.0
- ClinicalTrials.gov processing date: 22 September 2026.
- This page last checked by Voxsanity: 11 October 2026.
Voxsanity reformats data from public registries into this layout. It does not edit, interpret or add to what the registry published.
Not medical advice.
Individual trial records are refreshed on a rolling basis rather than all at once, so a record may be up to several weeks old. Each trial page and trial card shows the date its own record was last synced. Where a record has lagged, its status, sites and enrolment can differ from the current registry state in either direction, so check the registry link on the trial page before acting on them.
Orphanet citation
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Available on https://www.orphadata.com. Used under CC BY 4.0. Source: Orphanet / Orphadata (orphadata.com). Accessed 20 September 2026.
Hereditary Angioedema Type 2 is one of the rare diseases tracked on the Voxsanity rare disease hub, where you can compare it with every other rare condition we follow and filter trials by country.
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