Trial results
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to the results reported on ClinicalTrials.gov, this trial involved 77 people in total — 39 in the probiotic group and 38 in the placebo (dummy pill) group. The trial ran for eight weeks and was measuring nasal and sinus symptoms using a tool called the SNOT-20, which is a questionnaire where a score of 0 means no symptoms and 100 means the worst possible symptoms. The trial also tracked side effects, antibiotic use, and steroid nasal spray use during the eight weeks. The reported data shows that, on average, people in the probiotic group had a reduction of 1.8 points in their SNOT-20 symptom score over the eight weeks, while people in the placebo group had a reduction of 5.5 points. For side effects, 14 participants in the probiotic group and 17 in the placebo group reported at least one side effect. Regarding antibiotic use, the placebo group used antibiotics for an average of 1.9 days, compared to 0.8 days in the probiotic group. For steroid nasal spray use, the probiotic group averaged 2.8 days of use, while the placebo group averaged 0.4 days. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.
View full results on ClinicalTrials.gov ↗
These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
Phase 4 Chronic Rhinosinusitis Trial, Completed
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 15 and 70 years old.
- You have had a blocked nose on more than half of days over the last 3 months, lasting at least 12 weeks in a row.
- You have had a runny nose on more than half of days over the last 3 months, lasting at least 12 weeks in a row.
- An ear, nose, and throat (ENT) specialist has diagnosed you with chronic inflammatory rhinosinusitis (long-term swelling in the nose and sinuses, with thickened nasal lining or nasal polyps, and no active bacterial infection).
- You have access to a telephone, either at home or a personal mobile phone.
Who may not be able to join:
- You have had sinus surgery within the last 3 months.
- You have had an illness in the last 2 weeks that required antibiotics, such as an ear infection, sore throat, bronchitis, or laryngitis.
- You have a weakened immune system, whether due to medications (such as steroid tablets), or conditions such as autoimmune disease, HIV, cystic fibrosis, uncontrolled diabetes, chronic kidney failure, or cancer (confirm with trial site).
- You have been diagnosed with a bacterial sinus infection, either ongoing or recent.
- You have had an allergic reaction to a probiotic supplement in the past, such as chest tightness, difficulty breathing, hives, or a rash.
- You are unable to speak or read English.
- You are currently pregnant or breastfeeding.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Primary endpoints
Mean Reduction in SNOT-20 Scores
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.