Trial results
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to the results reported on ClinicalTrials.gov, this trial (NCT01685229) enrolled 198 people with chronic sinusitis — 146 in the balloon sinus dilation (BSD) group and 52 in the medical management group. The trial compared two approaches to managing chronic sinusitis over 52 weeks. It measured changes in participants' sinusitis symptoms and quality of life using several questionnaires, including the Chronic Sinusitis Survey (CSS), the Rhinosinusitis Disability Index (RSDI), and the Sino-Nasal Outcome Test (SNOT-20). By the end of the study, 120 people in the BSD group and 36 in the medical management group had completed it. The reported data shows that the main measure — change in total CSS score at 24 weeks — recorded an average improvement of 41.9 points (out of 100) in the BSD group, compared to 27.0 points in the medical management group. A higher score on this scale means fewer symptoms and less medication use. For the RSDI questionnaire (where a lower score means less impact from sinus disease), the reported data shows average reductions of around 34.7 to 36.0 points in the BSD group across different time points, compared to reductions of around 14.7 to 18.1 points in the medical management group. For the SNOT-20 questionnaire (also where lower is better), both groups reported reductions in scores across 12, 24, and 52 weeks, with the BSD group showing reductions of around 1.6–1.7 points and the medical management group showing reductions of around 0.9–1.0 points. Changes in medication use and missed days of work or school were also measured, with both groups showing some reductions over time; the specific figures for each time point are available in the full ClinicalTrials.gov record. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.
View full results on ClinicalTrials.gov ↗
These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
Chronic Rhinosinusitis Trial, Completed
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are a male or female aged 19 or older
- You have been diagnosed with a long-term sinus condition called Chronic Rhinosinusitis (CRS)
- Treatments you have already tried for your sinuses have not worked well enough
- Scans or imaging have shown signs of inflammation in your sinuses
- Your doctor has determined that you are a suitable candidate for sinus surgery
- You are willing and able to read and sign a consent form and follow the study's rules and procedures
- You are able to read and understand English
Who may not be able to join:
- Balloon dilation (a procedure to open the sinuses) is not a suitable treatment option for all of the sinuses you need treated
- You have a significant health condition that could affect how the study results are measured (confirm with trial site)
- You have taken part in another clinical study within the last 30 days
- You are currently pregnant or breastfeeding
- You are unable to attend follow-up appointments or meet the study's requirements
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
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Trial details
Where this trial is recruiting
Primary endpoints
Comparison of Change in Chronic Sinusitis Survey (CSS) Score at 24 Weeks Compared to Baseline
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.