HIV and AIDS Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
This trial has three groups. Please read the section that may apply.
Group 1: People with PML (a serious brain infection)
Who might be able to join this trial:
- People with a suspected or confirmed diagnosis of PML
- People whose MRI brain scan shows results consistent with PML
- People who are able to take part in the study visits and any required follow-up appointments
- People who are at least 2 years old
Who may not be able to join:
- People with a serious health condition that, in the lead investigator's judgement, would make taking part in the study unsafe or impossible (confirm with trial site)
- People who cannot safely have an MRI scan — for example, those with a cardiac pacemaker, infusion pump, other metal implants, metal foreign objects, or body piercings that cannot be removed
- People who are pregnant
- People who are unable to give informed consent themselves and do not have a legally authorised representative who can do so on their behalf
- People who are unwilling to consent to having biological samples (such as blood) collected and stored frozen for research
Group 2: People at Risk of PML (control group)
Who might be able to join this trial:
- People who are able to take part in the study visits and any required follow-up appointments
- People who are at least 2 years old
- People with a weakened immune system from any cause who are considered at risk of developing PML — for example, those with a history of blood cancer, chronic inflammatory disease, treatment with immune-suppressing or immune-modifying medications, or a primary or acquired immune deficiency condition
Who may not be able to join:
- People with a serious health condition that, in the lead investigator's judgement, would make taking part in the study unsafe or impossible (confirm with trial site)
- People who cannot safely have an MRI scan — for example, those with a cardiac pacemaker, infusion pump, other metal implants, metal foreign objects, or body piercings that cannot be removed
- People who are pregnant
- People who are unable to give informed consent themselves and do not have a legally authorised representative who can do so on their behalf
- People who are unwilling to consent to having biological samples (such as blood) collected and stored frozen for research
Group 3: Healthy Volunteers
Who might be able to join this trial:
- People who are able to take part in the study visits and any required follow-up appointments
- People who are at least 18 years old
Who may not be able to join:
- People with a weakened immune system — for example, those with a history of blood cancer, chronic inflammatory disease, treatment with immune-suppressing or immune-modifying medications, or a primary or acquired immune deficiency condition
- People with a serious health condition that, in the lead investigator's judgement, would make taking part in the study unsafe or impossible (confirm with trial site)
- People who cannot safely have an MRI scan — for example, those with a cardiac pacemaker, infusion pump, other metal implants, metal foreign objects, or body piercings that cannot be removed
- People who are pregnant
- People who are unable to give informed consent themselves and do not have a legally authorised representative who can do so on their behalf
- People who are unwilling to consent to having biological samples (such as blood) collected and stored frozen for research
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Irene CM Cortese, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Phone: (301) 496-3825
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
To characterize the baseline presentation of patients with JCV infection and/or PML with regard to clinical, radiological, immunological, genetic and viral features.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.