Trial results
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to the results reported on ClinicalTrials.gov, this trial involved 7 participants in total — 3 in one group and 4 in the other. It used a "crossover" design, meaning everyone tried both approaches: one group followed a low-salicylate diet for 7 days first, then switched to a normal diet for 7 days, while the other group did it in the opposite order. Salicylates are natural chemicals found in many foods. The trial was measuring several things in participants' urine, as well as their self-reported sinus and nasal symptoms. The reported data shows the following urine measurements after each diet period. For a substance called cys-leukotrienes (chemicals linked to inflammation), levels were 874.05 pg/ml on the low-salicylate diet and 771.99 pg/ml on the normal diet. For salicyluric acid (a breakdown product of salicylates), levels were 44.21 ng/ml on the low-salicylate diet and 23.82 ng/ml on the normal diet. For salicylic acid itself, levels were 0.60 ng/ml on the low-salicylate diet and 0.92 ng/ml on the normal diet. Creatinine (a substance used to help interpret urine tests) was measured at 9.9 mmol/L on the low-salicylate diet and 15.3 mmol/L on the normal diet. The reported data also shows results from a symptom questionnaire called the SNOT-22, which asks people to rate 22 sinus and nasal symptoms on a scale from 0 (no problem) to 5 (as bad as it can be), giving a total possible score of 0 to 110 — where a higher score means worse symptoms. Participants reported an average score of 44 during the low-salicylate diet period and 66 during the normal diet period. It is worth noting that only 7 people completed this trial, which is a very small number, and the data as submitted does not include any further statistical analysis of these results. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.
View full results on ClinicalTrials.gov ↗ · Read the linked publication on PubMed (PMID 33892819) ↗
These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
Chronic Rhinosinusitis Trial, Completed
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are an adult (18 years or older)
- You have a condition called Aspirin-exacerbated respiratory disease, which means your breathing symptoms get worse when you take aspirin or similar pain medications
Who may not be able to join:
- You have taken Prednisone or other steroid tablets/injections more than 3 times in the past 3 months
- You have had sinus surgery or nasal polyp removal surgery within the past 6 months
- You have another serious ongoing illness, such as kidney failure or a condition that weakens your immune system
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
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Trial details
Where this trial is recruiting
Primary endpoints
Urinary Levels of Cys-Leukotrienes; Urinary Salicyluric Acid Levels; Urinary Salicylic Acid Levels; Urinary Creatinine Levels
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.