Phase 4 Chronic Rhinosinusitis Trial, Completed (NCT01825408)

Phase 4 Chronic Rhinosinusitis Trial, Completed NCT01825408 Sponsor: University of North Carolina, Chapel Hill Condition: Chronic Rhinosinusitis

Printed from Voxsanity (voxsanity.com.au) — NCT01825408 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.

Back to Chronic Rhinosinusitis

Trial results

AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

According to the results reported on ClinicalTrials.gov, this trial involved 40 people in total with chronic sinusitis (long-term sinus inflammation). Participants were divided into four groups and given one of two antibiotics — doxycycline or azithromycin — for either three or six weeks. The trial was measuring how many people in each group were recommended for sinus surgery by their doctor after finishing their course of antibiotics. All 40 participants completed the trial. The reported data shows the following numbers for surgery recommendations. In the three-week treatment groups: out of 7 people taking doxycycline, 0 were recommended for surgery; out of 8 people taking azithromycin (noting the data lists 8 as the starting count for this comparison), 6 were recommended for surgery. In the six-week treatment groups: out of 5 people taking doxycycline, 2 were recommended for surgery; out of 8 people taking azithromycin, 4 were recommended for surgery. These numbers reflect what the treating doctors recorded based on each patient's ongoing symptoms and scan or camera results after treatment. It is important to note that the group sizes in this trial were very small, which means these figures should be understood only as the raw numbers recorded — not as broad conclusions about either antibiotic. No secondary outcome data appears to have been reported in the structured results submitted to ClinicalTrials.gov, so those figures are not available here. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.

View full results on ClinicalTrials.gov ↗

These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

You have been diagnosed with chronic rhinosinusitis (long-term inflammation or infection of the sinuses)
You are 18 years of age or older
You are able to speak and communicate in English

Who may not be able to join:

You are currently pregnant or breastfeeding
You have a condition called vasculitis (inflammation of the blood vessels) (confirm with trial site)
You have cystic fibrosis
You have a condition called primary ciliary dyskinesia, which affects how tiny hair-like structures in the body move (confirm with trial site)
You have allergic fungal sinusitis (a type of sinus condition caused by a fungal allergy)
You have a serious problem with your immune system that significantly affects how your body fights infection
You are currently receiving chemotherapy treatment
You have diabetes that requires insulin to manage
You have recently completed a full course of the strongest available medical treatment for your sinus condition (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.

Last synced 28 July 2026

Phase 4 trials study a drug that has already been approved, monitoring long-term safety and effectiveness in real-world use.

GP referral letter

Print a one-page summary to share with your doctor.

Voxsanity

Clinical trials and treatments, explained plainly · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I found the following past clinical trial relevant to my condition, and wanted to raise it with you. It is no longer recruiting, but I wanted to ask whether similar active trials exist, or whether its results are relevant to my care:

Trial: NCT01825408

Sponsor: University of North Carolina, Chapel Hill

Phase: Phase 4

Status: Completed

Condition: Chronic Rhinosinusitis

More information: https://clinicaltrials.gov/study/NCT01825408

Eligibility summary (AI generated)

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

You have been diagnosed with chronic rhinosinusitis (long-term inflammation or infection of the sinuses)
You are 18 years of age or older
You are able to speak and communicate in English

Who may not be able to join:

You are currently pregnant or breastfeeding
You have a condition called vasculitis (inflammation of the blood vessels) (confirm with trial site)
You have cystic fibrosis
You have a condition called primary ciliary dyskinesia, which affects how tiny hair-like structures in the body move (confirm with trial site)
You have allergic fungal sinusitis (a type of sinus condition caused by a fungal allergy)
You have a serious problem with your immune system that significantly affects how your body fights infection
You are currently receiving chemotherapy treatment
You have diabetes that requires insulin to manage
You have recently completed a full course of the strongest available medical treatment for your sinus condition (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.

Access in Australia: A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a doctor to access unapproved therapeutic goods for individual patients. See voxsanity.com.au/sas-navigator/ for a plain English explainer.

This information was sourced from ClinicalTrials.gov via Voxsanity (data last synced 28 July 2026). It is not medical advice. Please verify the trial's current status directly with the trial site before acting.

Trial details

Status

Completed

Phase

Phase 4

Sponsor

University of North Carolina, Chapel Hill

Registry

ClinicalTrials.gov

Start date

1 February 2013

Est. completion

1 June 2014

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Number of Patients Recommended for Sinus Surgery After 3 Weeks of Antibiotic Therapy; Number of Patients Recommended for Sinus Surgery After 6 Weeks of Antibiotic Therapy

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

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Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov