Trial results
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to the results reported on ClinicalTrials.gov, this trial involved 89 people with chronic sinusitis who were having sinus surgery. Participants were randomly split into two groups: 43 people received a combination antibiotic (amoxicillin-potassium clavulanate) and 46 received a placebo (a dummy treatment with no active medicine). The trial was measuring two main things: how people felt about their sinus symptoms using a questionnaire called the SNOT-22 (where higher scores mean worse symptoms, on a scale of 0 to 110), and how the sinuses looked during a camera examination using a scoring system called the Lund Kennedy score (where higher scores mean more disease visible, on a scale of 0 to 20). The reported data shows that at the start of the study, both groups had very similar SNOT-22 symptom scores — 31.3 for the antibiotic group and 31.0 for the placebo group. At a later follow-up point, the antibiotic group's score had dropped to 22.3, while the placebo group's score had dropped to 17.5. For the camera examination scores, the reported data shows starting scores of 5.6 (antibiotic group) and 5.9 (placebo group), which later shifted to 4.3 and 4.5 respectively. The trial did not report whether the differences between the two groups were considered meaningful beyond these raw numbers. The reported data also shows that post-operative infections were recorded as an additional measure. In one time period, 1 participant in the antibiotic group and 0 in the placebo group had a post-operative infection recorded; in a second time period, no infections were recorded in either group. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.
View full results on ClinicalTrials.gov ↗ · Read the linked publication on PubMed (PMID 33340285) ↗
These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
Phase 4 Chronic Rhinosinusitis Trial, Completed
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with chronic sinusitis (long-term inflammation or infection of the sinuses) as defined by recognised medical guidelines
- Your doctor has decided you need surgery because your symptoms have not improved after trying the maximum level of medical treatment
- Your previous treatment included a course of antibiotics (either broad-spectrum or chosen based on a culture test) used together with a steroid nasal spray
Who may not be able to join:
- You are allergic to penicillin, cephalosporin, or amoxicillin/clavulanate (types of antibiotics)
- You have Cystic Fibrosis
- You have a weakened or impaired immune system
- You have any packing material (dissolving or non-dissolving) left in place after your surgery
- Your sinus problems are caused by a dental or tooth-related issue
- You have a fungal ball (a clump of fungus) in your sinuses
- You have an infected mucocele (a blocked, mucus-filled sac in the sinuses)
- You have developed serious complications from sinusitis, such as meningitis, an eye/eye socket problem, a skin infection (cellulitis), or a brain abscess
- Your sinus surgery is not done using an endoscope (a small camera inserted through the nose) — for example, if it involves older open surgical techniques
- You are under 18 years of age
- You are pregnant
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Sinonasal Outcome Test - 22; Sinonasal Outcome Test - 22
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.