NCT02032823

Who might be able to join this trial:

• You have been diagnosed with breast cancer that has not spread to other parts of the body, and the cancer has been confirmed by a tissue sample (biopsy).
• Your breast cancer is either "triple negative" (meaning it does not respond to certain hormone or targeted therapies) or hormone receptor-positive but HER2-negative (a specific type based on lab tests).
• You carry an inherited gene change (mutation) in either the BRCA1 or BRCA2 gene that is known or expected to be harmful.
• You have already had appropriate surgery on your breast and underarm lymph nodes.
• You have completed at least 6 cycles of chemotherapy (either before or after surgery) using drugs from the anthracycline or taxane families, or both; previous platinum-based chemotherapy for breast or other cancers (such as ovarian) is also allowed.
• You are in generally good physical health and able to carry out daily activities with little or no limitation (confirm with trial site).

Who may not be able to join:

• You have previously been treated with a type of drug called a PARP inhibitor (such as olaparib), or you have a known allergy to the ingredients in the study treatment.
• You have been diagnosed with another cancer, unless it is certain limited exceptions such as: non-melanoma skin cancer that was fully treated, cervical cancer in situ that was cured, non-invasive breast cancer (DCIS), or a very early-stage womb cancer; or another solid cancer or lymphoma diagnosed at least 5 years ago, fully treated with no signs of return, and treated with no more than one course of chemotherapy.
• You are currently taking certain medicines that strongly or moderately interfere with how the study drug is processed by your body — this includes some antifungals, antibiotics, heart medications, and HIV treatments, among others (confirm with trial site for your specific medications); a waiting period of 2–5 weeks off these medicines may be required before joining.
• You are currently taking certain other medicines that speed up the breakdown of the study drug in your body, such as some epilepsy medications, tuberculosis drugs, or St John's Wort (a herbal supplement); a waiting period of 3–5 weeks off these medicines may be required before joining.
• Your breast cancer has spread to other parts of your body (metastatic disease).

Important: Always verify eligibility with the trial site directly before applying.