Trial results
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to the results reported on ClinicalTrials.gov, this trial (NCT02182492) enrolled 187 people with chronic sinus conditions who had already undergone endoscopic sinus surgery (a procedure to clear the nasal passages). Participants were split into two groups — 93 received a glucocorticoid (a type of steroid-based nasal treatment) and 94 received clarithromycin (an antibiotic-type medicine) — with treatment starting one week after surgery. The trial measured two main things over 12 months: how participants rated their own symptoms on a questionnaire, and how a doctor scored the appearance of the nasal passages using a small camera. By the end of the study, 86 people in each group had completed the trial. The reported data shows that both groups started with similar self-reported symptom scores just before the surgery began (20.4 for the glucocorticoid group and 20.7 for the clarithromycin group, on a scale of 0–50 where higher means more severe). At the 12-month mark, the glucocorticoid group's score had dropped to 5.6, while the clarithromycin group's score had dropped to 4.8. For the nasal camera assessment (scored 0–22, with higher meaning more severe), starting scores were 8.2 and 7.6 respectively, and at 12 months these had fallen to 2.7 for the glucocorticoid group and 2.1 for the clarithromycin group. A third outcome — measuring inflammatory proteins in tissue samples — was listed in the trial but no numerical data was reported for it on ClinicalTrials.gov. The reported data shows that scores in both groups were lower at each follow-up check-in compared to where they started, across both the symptom questionnaire and the camera assessment. No data was reported comparing the two groups directly against each other in a way that would indicate which performed better. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.
View full results on ClinicalTrials.gov ↗
These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
Chronic Rhinosinusitis Trial, Completed
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with chronic rhinosinusitis (long-term inflammation of the sinuses and nasal passages), either with or without nasal polyps, based on recognised medical guidelines
- You are between 16 and 70 years old
- You are Chinese
- Your condition has not improved enough with standard medical treatments, as recommended by established guidelines
Who may not be able to join:
- You are pregnant or currently breastfeeding
- You have cystic fibrosis
- You have a condition where the tiny hair-like structures in your airways do not work properly from birth (confirm with trial site)
- You have a fungal infection in your sinuses or nasal passages
- You have a condition where your immune system attacks your blood vessels (confirm with trial site)
- You have a disease that causes areas of inflammation to form in your body's tissues (confirm with trial site)
- You have a tumour
- You have a weakened immune system
- You are allergic to the antibiotic clarithromycin or to steroid nasal sprays/drops
- You have had a cold or upper airway infection in the 4 weeks before joining the study
- You have a serious condition affecting your heart, lungs, blood, digestive system, brain, nerves, or metabolism, or any condition such as glaucoma or tuberculosis that could affect your safety or the study results
- You have emotional or mental health problems
- You have received immunotherapy treatment in the last 3 months
- You have taken steroid or macrolide antibiotic medications (locally or throughout the body) in the last 4 weeks
- You have had an acute asthma attack in the 4 weeks before joining the study
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
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Trial details
Where this trial is recruiting
Primary endpoints
Total Subjective Symptoms Visual Analog Scores (VAS)
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Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.