Phase 2 Chronic Rhinosinusitis Trial, Completed

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 70 years old
• You are willing to use effective birth control during the study and for 1 month after the last dose (if female) or 3 months after the last dose (if male)
• You have been officially diagnosed with chronic sinusitis with nasal polyps
• Your medical records show a history of high levels of a type of white blood cell called eosinophils in your nose
• A recent blood test shows your eosinophil count is above 300 cells per microlitre
• Your nasal polyps score at least 4 out of the maximum on both sides of your nose combined (confirm with trial site)
• You scored above 7 on a standard questionnaire about nose and sinus symptoms called the SNOT-22
• You are currently using a steroid nasal spray or rinse at a low-to-moderate dose (confirm with trial site)

Who may not be able to join:

• You have had an acute sinus infection, nasal infection, or any upper respiratory infection in the 2 weeks before the study starts
• Your CT scan suggests a specific type of fungal sinus condition (confirm with trial site)
• Your nasal septum is bent enough to fully block at least one nostril
• You have had nasal surgery, including polyp removal, within the past 6 months
• You have had more than 5 sinus or nasal surgeries that required general anaesthesia
• You have had more than 2 sinus or nasal surgeries that involved changing the inner wall structure of your nose
• You have a history of cystic fibrosis, a condition affecting how the tiny hairs in your airways work, or Kartagener's syndrome
• You have ever been diagnosed with a parasitic infection
• You have been hospitalised or needed emergency treatment for asthma 2 or more times in the past 12 months
• You were hospitalised for a severe asthma attack within the past 4 weeks
• Your lung function test shows your breathing capacity is below 60% of the normal expected level for someone your age and size
• You have used steroid tablets or injections, or had steroids injected directly into a polyp, within the past 8 weeks, or you are likely to need them during the study
• You have needed emergency steroid tablets for asthma or sinus flare-ups more than once in the past year
• You have taken part in another clinical drug trial within the past 30 days or within a certain time frame based on the drug used (confirm with trial site)
• You have received a biologic therapy (a type of targeted medicine, such as omalizumab/Xolair) within a certain recent time period (confirm with trial site)
• You have taken a medication called zileuton (Zyflo) within the past 4 weeks
• You have taken a medication called pramipexole (Mirapex) within the past 4 weeks
• You have a history of cancer, including blood cancers or solid tumours (except certain fully treated and cured minor skin cancers)
• You have a history of HIV, hepatitis B, or hepatitis C
• You have a serious or unstable heart, liver, or kidney condition, or another significant health problem
• You have any medical or personal situation that might prevent you from completing the study visits or following the study requirements
• Your blood test shows a low level of a type of immune cell called neutrophils, or you have a history of having low neutrophil levels
• Your blood test shows a very high level of a protein called IgE (above 1500 IU/ml)
• Your kidneys are not filtering at a normal level based on a specific blood test (confirm with trial site)
• You have a history of a heart rhythm condition called long QT syndrome or other irregular heartbeat
• Your heart tracing (ECG) shows a prolonged QT interval at the screening stage or before your first dose
• Your resting ECG shows certain other abnormalities that could affect how results are interpreted, including an unusually long PR interval, a wide QRS reading, or a heart rate that is too slow or too fast (confirm with trial site)
• You are currently pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.