NCT02670083

Who might be able to join this trial:

• You weigh between 40 and 120 kilograms (about 88 to 265 pounds)
• You have someone in your life (like a family member or close friend) who sees you regularly, can accurately describe your memory and daily functioning, is willing to attend clinic visits and sign a consent form, and has good enough memory themselves to report on your condition
• You are fluent in the language used for the tests at the study site
• You have good enough vision and hearing to complete memory and thinking tests (glasses and hearing aids are allowed)
• Testing of your spinal fluid or a brain scan shows signs of Alzheimer's-related changes (specifically, a protein called amyloid)
• Memory tests done at or shortly before your screening visit show abnormal memory function (based on specific test scores — confirm with trial site)
• Your score on a standard memory and thinking test (called the MMSE) is 22 or higher, and a doctor's rating of your daily functioning falls within a specific range (called CDR-GS 0.5 or 1.0)
• A doctor has diagnosed you with probable Alzheimer's disease or early-stage memory impairment consistent with Alzheimer's, following recognised medical guidelines
• If you are already taking medication for Alzheimer's symptoms, your dose has stayed the same for at least 3 months before the screening visit
• You have completed at least 6 years of formal schooling after the age of 5

Who may not be able to join:

• You have a condition other than Alzheimer's that affects memory or thinking, such as another type of dementia, stroke, brain injury, certain autoimmune diseases (like multiple sclerosis), or a past infection that affected the brain
• You have a history of serious mental illness, such as schizophrenia, or depression that is not currently under control
• The study doctor has concerns that you may be at risk of harming yourself
• Your MRI brain scan shows certain abnormalities (such as signs of blood vessel problems or a past stroke), you are unable to tolerate an MRI scan, or you have a medical reason you cannot have an MRI
• You have an unstable or serious heart, kidney, or liver condition (for example, a recent heart attack)
• Your blood pressure is not well controlled
• A blood test at screening shows your blood sugar control is poor (HbA1c above 8%)
• Your veins make it difficult to take blood samples
• You have a history of cancer, unless it is considered fully treated/cured or you are not currently receiving cancer treatment or radiotherapy
• You have had a serious allergic reaction (including anaphylaxis) to certain types of antibody-based medicines in the past (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.