Hearing Loss Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with Wolfram syndrome and have access to the internet.
• You developed diabetes (high blood sugar) before the age of 16 AND/OR experienced vision loss due to optic nerve damage before the age of 16 (these are the main qualifying conditions).
• You may also qualify if you meet one of the main conditions above plus at least two of the following: diabetes insipidus (a water-regulation condition), diabetes or optic nerve damage first appearing after age 16, hearing loss caused by nerve damage, neurological signs such as balance problems, seizures, or memory/thinking difficulties, kidney or urinary tract problems, a specific gene mutation in WFS1 or CISD2, or a family history of Wolfram syndrome.
• You may qualify if two disease-causing mutations are found in the WFS1 or CISD2 genes, even without the main criteria above.
• Children and minors are encouraged to participate, as the disease often begins in childhood.
• Unaffected parents, brothers, sisters, or spouses of patients may also be able to join as comparison participants.

Who may not be able to join:

• You or your guardian are unable to get help with translation and therefore cannot understand the questionnaire.
• Family members who wish to join as comparison participants but cannot understand the informed consent document may not be eligible.

Important: Always verify eligibility with the trial site directly before applying.