Trial results
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to the results reported on ClinicalTrials.gov, this trial (NCT03369717) enrolled 24 people in total — 12 in a group that received antibiotics after sinus surgery, and 12 in a group that did not receive antibiotics. The trial was looking at whether taking antibiotics after surgery made a difference to rates of post-surgical infection, as well as how participants felt about their sinus-related symptoms and how their sinuses appeared on examination at follow-up visits. The reported data shows that a relatively small number of participants completed the study — 2 in the antibiotics group and 4 in the no-antibiotics group — with the remaining participants not completing it. The reported data shows that for the main outcome — confirmed bacterial infection after surgery — 1 participant in the antibiotics group had a recorded infection, while 0 participants in the no-antibiotics group had one. For the secondary outcomes, participants' self-reported symptom scores (measured on a questionnaire called the SNOT-22, where higher numbers out of 110 mean more bothersome symptoms) were broadly similar between the two groups across the follow-up visits, with scores ranging from around 21 to 25 in both groups. A separate measure of how the sinuses looked on examination (scored from 0 to 10, where higher means more signs of disease) also showed similar patterns in both groups, with scores ranging from approximately 3.5 to 5.4 across visits and groups, and generally decreasing over time. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.
View full results on ClinicalTrials.gov ↗
These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
Phase 4 Chronic Rhinosinusitis Trial, Terminated
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You have been diagnosed with chronic sinusitis (long-term inflammation of the sinuses), with or without nasal polyps, or a related condition called allergic fungal rhinosinusitis
- Your doctor has recommended you have sinus surgery on both sides of your nose (a procedure called bilateral endoscopic sinus surgery)
- You are 18 years of age or older
- You are being seen at an ear, nose, and throat (ENT) clinic
Who may not be able to join:
- You have a tumor in your nose or sinuses
- You are allergic or have had a bad reaction to all three of the antibiotics used in this study (amoxicillin-clavulanate, doxycycline, and clarithromycin)
- You have a weakened immune system
- You have cystic fibrosis
- You are pregnant
- You have diabetes and also have nasal polyps, because this would prevent you from safely taking steroid medication
- You are not able to give informed consent for yourself
- You are currently receiving treatment for cancer
- You are only having surgery on one side of your nose, or you will have a certain type of non-dissolving packing placed in your nose during surgery
- You have taken antibiotics within 2 weeks before your surgery date
- You have a sudden flare-up of your sinusitis on top of your chronic condition, or there is an active infection with pus present at the time of surgery
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Postoperative Infection
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.