Heart Disease Trial, Recruiting NCT03398369 Sponsor: University of Virginia Condition: Heart Disease
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Heart Disease Trial, Recruiting

NCT03398369
Recruiting Not Applicable

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have long-term heart failure where the heart's main pumping chamber is not squeezing properly (known as systolic heart failure)
  • People whose heart's pumping strength (called ejection fraction) is 35% or lower
  • People whose doctors have recommended a specific heart device called cardiac resynchronisation therapy (CRT) based on standard medical guidelines, at either a Class I or Class II level of recommendation (confirm with trial site)

Who may not be able to join:

  • People who are unable to give their own informed consent to participate
  • People who are pregnant
  • People who have metal fragments in their body from a past accident or injury, confirmed by X-ray or other imaging
  • People who have surgical clips in the brain used to treat a burst blood vessel (cerebral aneurysm)
  • People who have a cochlear implant (a hearing device implanted in the ear)
  • People who have other metal implants that are known to be unsafe during a heart MRI scan — note that pacemakers and ICDs (implanted heart devices) are not automatically excluded under this criterion (confirm with trial site)
  • People who experience severe claustrophobia (extreme fear of enclosed spaces, such as an MRI machine)
  • People who have sudden, recent kidney damage (acute kidney injury)
  • People who have sudden kidney failure or long-term kidney disease where the kidneys are not filtering blood well enough (a specific filtering rate below 45 cc/min/1.73m²)
  • People who have had a liver transplant
  • People who have a known allergy to gadolinium (a contrast dye used in MRI scans)
  • People whose hearts show more than 10% of beats as irregular extra heartbeats from the lower chambers (premature ventricular contractions)
  • People whose available health records suggest they are in an irregular heart rhythm called atrial fibrillation more than 10% of the time

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 19 July 2026
This study is not part of the standard drug-approval phase pathway (for example an observational, device, behavioural, or registry study), so a phase success rate does not apply.

Contact this trial

Principal Investigator: Kenneth C Bilchick, MD, University of Virginia Health System

Phone: 4349242465

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Not Applicable
Registry
ClinicalTrials.gov
Start date
5 January 2018
Est. completion
15 January 2025

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Left ventricular end-systolic volume (LVESV) improvement

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 19 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov