Sjogren's Syndrome Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been formally diagnosed with primary Sjögren's syndrome
• You are over 18 years old
• You have not received biologic medications or intravenous immunoglobulin therapy in the 6 months before the study starts

If joining the main study group (Arm 1):

• You have symptoms suggesting damage to small nerve fibres — such as reduced ability to feel heat or pain, problems with automatic body functions (like sweating or heart rate), or nerve pain scoring 4 or above on a specific pain questionnaire
• AND you also have at least one abnormal test result, such as nerve function tests (measuring temperature/pain sensitivity or sweat responses) OR a skin biopsy showing reduced nerve fibre density

If joining the control group (Arm 2):

• You have Sjögren's syndrome but show no signs of nerve damage (either small or large nerve fibres)

Who may not be able to join:

• You have another known condition that can cause nerve damage, such as diabetes, alcoholism, HIV, coeliac disease, sarcoidosis, Guillain-Barré syndrome, certain drug or toxic exposures, or specific inherited conditions affecting the nerves (confirm with trial site)
• You have symptoms that suggest small nerve fibre damage (such as reduced heat/pain sensation, automatic body function problems, or significant nerve pain), but all your diagnostic tests — including nerve function tests and skin biopsy — have come back normal

Important: Always verify eligibility with the trial site directly before applying.