Phase 2 HIV and AIDS Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are over 18 years old
• People who are able to read and understand a written consent form
• People who have HIV, and who either: are currently taking a combination HIV treatment (ART) regimen, have never taken HIV treatment, or have taken HIV treatment in the past but stopped at least 1 week before the study's imaging session
• People whose recent blood test results (taken within the last 60 days) show that platelet counts, white blood cell levels, liver function, kidney function, and immune cell counts (CD4+ T cells, for those with HIV) are all within the required ranges (confirm specific numbers with trial site)

Who may not be able to join:

• People who cannot have an MRI scan — for example, those with a permanent pacemaker, metal implants or prosthetics, an aneurysm clip, a non-removable piercing, or severe claustrophobia
• People with a medical condition that, in the opinion of the trial doctor, would affect the quality of the scan images
• People who have received treatments that affect the immune system (other than an HIV DNA vaccine) within the past 60 days
• People who are currently pregnant (pregnancy testing will be done before the imaging agent is given, and a positive result will mean the person cannot continue in the study)
• People who are currently breastfeeding
• Women who could become pregnant (meaning those who have had a period in the last 24 months, or have not had a hysterectomy and/or removal of both ovaries or both fallopian tubes) must have a negative pregnancy test at the first visit and again within 24 hours before the PET scan, and must use 2 forms of contraception (withdrawal or timing-based methods do not count)
• People who have previously had a stem cell transplant or solid organ transplant from another person
• People whose recent blood tests show platelet counts, white blood cell counts, red blood cell levels, kidney function, or liver function outside the required ranges (confirm specific values with trial site)
• People who have been hospitalised or needed intravenous antibiotics for a serious illness within the past 3 months
• People who currently have an active HIV-related opportunistic infection, such as a specific type of pneumonia, widespread bacterial infection, invasive fungal infection, a throat yeast infection, or a brain parasite infection (a mild oral yeast infection is acceptable)
• People who have previously been diagnosed with a bone marrow disorder called myelodysplasia, or who have a history of a blood or lymph system cancer
• People with a documented history of heart failure that required medication, or that needed medical management within the past year
• People with an active Hepatitis C infection (people who were previously treated for Hepatitis C and have no remaining signs of the virus may still be eligible — confirm with trial site)
• People with an active autoimmune disease affecting the whole body
• People who have had a routine vaccination within the 14 days before entering the study

Important: Always verify eligibility with the trial site directly before applying.