Sleep Disorders Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between the ages of 56 and 85 years old
• People who score 18 or above on a memory and thinking test called the Montreal Cognitive Assessment (MoCA)
• People whose level of daily functioning is not significantly affected by memory problems, as measured by a standard rating scale called the Clinical Dementia Rating (CDR) — specifically, a total score below 1 (confirm with trial site)
• People who are willing to have two blood draws for biomarker testing over the course of the study (note: as of August 2024, the spinal fluid collection procedures previously part of this trial have been removed)
• People who are willing and able to stop using prescription or non-prescription sleep aids — such as Ambien, Melatonin, Lunesta, or similar products — for the entire duration of the study, except for any medications provided by the study
• People with a Body Mass Index (BMI) below 35 at the time of joining the study
• People who are willing to bring a spouse, child, or close friend who knows them well to each of the four study visits

Who may not be able to join:

• People who have sleep apnea and do not use a CPAP machine, or who have chronic lung conditions such as COPD or emphysema
• People with a major psychiatric diagnosis such as bipolar disorder or schizophrenia
• People with a history of alcohol or drug abuse
• People diagnosed with a brain or nervous system condition such as Parkinson's disease, Lewy body disease, ALS, or multiple sclerosis
• People who have previously had a stroke or a traumatic brain injury
• People who have undergone chemotherapy in the past 2 years
• People who have been hospitalised for an injury or surgery in the past 3 months
• People whose CDR score is 1 or higher, or who have clinically significant depression or anxiety as measured by standard rating scales (confirm with trial site)
• People currently taking any of the following types of medication: Fluvoxamine (Luvox) or Fluoxetine (Prozac); Nifedipine (a blood pressure medication); blood thinners such as Warfarin, Xarelto, or Heparin; anti-seizure medications such as Gabapentin or Carbamazepine; muscle relaxants such as Valium or Baclofen; or narcotic pain relievers such as Codeine, Tramadol, or Hydrocodone

Important: Always verify eligibility with the trial site directly before applying.