Trial results
AI generated results summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
According to the results reported on ClinicalTrials.gov, this trial looked at three different doses of a nasal rinse containing mometasone (a steroid medication) — 1 mg, 2 mg, and 4 mg. The trial was measuring whether using this rinse continuously could affect levels of a hormone called cortisol in the blood. Cortisol is a natural hormone your body produces, and when people use steroid-based treatments, one thing researchers sometimes check is whether the body's own cortisol production is being reduced (known as "suppression"). A total of 16 people started and completed the trial — 2 in the 1 mg group and 14 in the 2 mg group. No participants were enrolled in the 4 mg group. The reported data shows that cortisol was measured in the morning — a standard time to check this hormone. For the 1 mg group, the average reported morning cortisol level was 17.35 micrograms per decilitre (mcg/dL), and for the 2 mg group it was 14.48 mcg/dL. No cortisol data was reported for the 4 mg group, as no participants were enrolled in that arm. No other outcome measures appear to have been submitted to ClinicalTrials.gov for this trial. It is worth noting that the 1 mg group included only 2 participants, which is a very small number, and no results for the 4 mg dose were available. These are the results as reported to ClinicalTrials.gov. They are not medical advice — always discuss what they mean for you with your doctor.
View full results on ClinicalTrials.gov ↗ · Read the linked publication on PubMed (PMID 26750509) ↗
These are the results as reported to ClinicalTrials.gov, not medical advice. Verify independently with the trial site and discuss what they mean for you with your doctor.
Phase 1 Chronic Rhinosinusitis Trial, Completed
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are 18 years of age or older
- You have been diagnosed with Chronic Rhinosinusitis (long-term sinus inflammation), with or without nasal polyps
- You have previously had sinus surgery using a camera (called endoscopic sinus surgery)
- Your past surgery must have included removal of specific sinus tissue and widening of a sinus opening (confirm with trial site if unsure whether your surgery qualifies)
Who may not be able to join:
- You have taken steroid tablets or injections (such as prednisone) within the last month
- You have a condition where your adrenal glands do not work properly (adrenal insufficiency)
- You have a liver disease or liver condition
- You are a woman currently taking estrogen medication by mouth (oral estrogens)
- You have a BMI (body mass index) over 38
- You are currently pregnant
- You are taking certain medications that affect a hormone system in the body called the HPA axis (confirm with trial site which medications apply)
- You have been diagnosed with any of the following conditions: cystic fibrosis, sarcoidosis, problems with how your cilia (tiny hairs in the airway) move, widespread blood vessel inflammation, low levels of certain immune proteins (IgG or IgA deficiency), or a known problem with your pituitary or adrenal glands
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Morning "AM" Serum Cortisol Level
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.