Phase 2 Hearing Loss Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have tinnitus (ringing in the ears) that is at least moderately severe, based on a specific questionnaire score, and it is linked to blast or loud noise exposure, a head injury, or a concussion diagnosed by a healthcare provider
• You are 18 years of age or older
• You are able to read and sign a consent form agreeing to take part
• You have stopped any other tinnitus treatments or programs for at least 4 weeks before joining (hearing aids are allowed if you have been using them for at least 4 weeks)
• Your tinnitus is constant — not coming and going or pulsing in rhythm with your heartbeat
• Your tinnitus can be heard in one ear, both ears, or inside your head
• All levels of hearing ability are welcome, including those with very severe hearing loss in both ears

Who may not be able to join:

• You have a history of serious brain conditions such as stroke, Parkinson's disease, ALS, Huntington's disease, multiple sclerosis, or other diseases affecting the nerves or brain — or you have had brain surgery (though certain specific procedures such as removal of a blood clot on the brain may be allowed — confirm with trial site)
• You currently have or have had cancer, except for certain skin cancers or cervical cancer that have been successfully treated
• You have been diagnosed with congestive heart failure (a condition where the heart does not pump blood effectively)
• You have a history of seizures or epilepsy
• You have certain blood or bone marrow disorders, or your blood cell or platelet counts are below a certain level (confirm with trial site)
• You currently have an active infection, including tuberculosis, HIV, hepatitis B (including a dormant/latent form), or chickenpox
• You have received a live vaccine within 2 weeks before the study starts, or you are scheduled to receive one during the study
• You have an autoimmune disease that weakens your immune system (autoimmune thyroid disease is not considered a reason to be excluded)
• You have diabetes
• You are currently taking or planning to take certain medications, including some used for cancer, immune system conditions, or blood sugar management (confirm with trial site for the full list)
• You are not able to reliably communicate with the research team or complete the study requirements, as judged by the study doctor
• You have taken part in another drug clinical trial in the last 30 days
• You are pregnant or planning to become pregnant during the study
• You are breastfeeding, or you are of childbearing age and not using contraception
• You scored below a certain level on a short memory and thinking assessment (confirm with trial site)
• Your routine blood test results are significantly outside the normal range, as decided by the study doctor

Important: Always verify eligibility with the trial site directly before applying.