Phase 2 Hearing Loss Trial, Recruiting NCT04077099 Sponsor: Regeneron Pharmaceuticals Condition: Hearing Loss
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Phase 2 Hearing Loss Trial, Recruiting

NCT04077099
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been diagnosed with advanced non-small cell lung cancer (NSCLC) that cannot be removed by surgery or has spread to other parts of the body, confirmed by a lab test on a tissue sample
  • You are willing to provide a sample of your tumor tissue as required by the trial
  • Your cancer has been shown to have a specific change (alteration) in a gene called MET
  • You are generally able to carry out daily activities with little or no limitation (confirm with trial site what level of ability is required)
  • Your organs (such as kidneys and liver) and bone marrow are working well enough as measured by blood tests

Who may not be able to join:

  • You have received an approved cancer treatment or taken part in another experimental drug study within the last 2 weeks
  • You are still experiencing significant side effects from a previous cancer treatment that have not yet gone away
  • You have had radiation therapy or major surgery within the last 14 days
  • You have a brain tumor, cancer that has spread to the brain or spinal fluid, or spinal cord compression that has not been treated or is currently active (confirm with trial site for specific details)
  • You currently have an infection that is not under control

Important: Always verify eligibility with the trial site directly before applying.

Note: This is a summary of the main criteria only. Additional requirements exist — the trial team will review your full medical history to confirm whether you qualify.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Clinical Trial Management, Regeneron Pharmaceuticals

Phone: 844-734-6643

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Regeneron Pharmaceuticals
Registry
ClinicalTrials.gov
Start date
7 January 2020
Est. completion
22 April 2032

Where this trial is recruiting

🇫🇷 France 🇰🇷 South Korea 🇺🇸 United States

Primary endpoints

Number of patients with Dose Limiting Toxicities (DLTs); Incidence and severity of treatment-emergent adverse events (TEAEs); Incidence and severity of adverse events of special interest (AESIs); Incidence and severity of serious adverse events (SAEs); Incidence and severity of grade ≥3 laboratory abnormalities; REGN5093 concentrations in serum over time; Objective response rate (ORR) per RECIST 1.1

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov