Phase 2 Liver Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 75 years old
• People who have been diagnosed with hepatocellular carcinoma (a type of liver cancer) confirmed by tissue or cell testing
• People whose liver cancer has been classified at a mid-to-advanced stage (BCLC stage B or C)
• People with a physical functioning score of 0–2 on a standard medical scale called ECOG PS, meaning the person can still carry out some daily activities (confirm with trial site)
• People whose liver function has been rated as Class A or B on a standard scoring system called Child-Pugh
• People for whom surgery to remove the tumour or a liver transplant has been assessed as not suitable
• People who have not yet received any systemic (whole-body) treatment for this cancer
• People who have at least one measurable tumour visible on a CT or MRI scan
• People whose expected survival time is at least 12 weeks
• People with a hepatitis B infection where the virus level in the blood is below 500 IU/mL and who are receiving standard antiviral treatment; people with hepatitis C must also be receiving standard antiviral treatment
• People whose major organs are functioning normally
• People who have signed a consent form agreeing to take part in the study

Who may not be able to join:

• People who have a different type of liver or bile duct cancer, such as cholangiocarcinoma, mixed hepatocarcinoma, or fibrolamellar hepatocellular carcinoma, or who have had another cancer that cannot be cured within the past five years
• People who have had local tumour ablation, a procedure called TACE (a targeted liver treatment), or radiotherapy within the three months before joining
• People who are planning to have, or have already had, an organ or bone marrow transplant
• People with ascites (fluid build-up in the abdomen), hepatic encephalopathy (brain problems caused by liver disease), or enlarged veins in the oesophagus or stomach that are not controlled
• People with high blood pressure that cannot be brought down to a normal level with blood pressure medication
• People with certain heart conditions, including a specific type of reduced blood supply to the heart, a history of heart attack, or an uncontrolled irregular heartbeat
• People who have conditions that would make it difficult for oral (swallowed) medications to work properly, such as an inability to swallow, long-term diarrhoea, or a blocked bowel
• People who have had bleeding in the stomach or digestive tract within the past six months
• People who have an abnormal connection between organs (fistula), a hole in the digestive tract (perforation), or an abscess (pocket of infection) in the abdomen
• People with serious lung conditions, including lung scarring, interstitial pneumonia, dust-related lung disease, radiation-related lung damage, or significantly reduced lung function
• People whose urine tests show a high level of protein in the urine (confirm with trial site for specific values)
• People who have an autoimmune disease (where the immune system attacks the body's own tissues)
• People who require ongoing treatment with corticosteroids or other medicines that suppress the immune system
• People who have received an anti-cancer vaccine or other immune-stimulating anti-cancer treatment within the three months before joining
• People who have a known allergy to monoclonal antibody medicines (a type of targeted therapy)
• People who are pregnant or breastfeeding

Important: Always verify eligibility with the trial site directly before applying.