Phase 4 Heart Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have had a serious heart event (called acute coronary syndrome) and are considered at high risk of future heart problems, and who have had a successful procedure to open blocked arteries (PCI) with at least one drug-coated stent placed
• People who are willing and able to give their consent to participate and to attend follow-up appointments over 12 months
• People for whom dual antiplatelet therapy (a combination of blood-thinning medicines to prevent clots) is a suitable treatment option
• To be eligible, a person must meet at least one clinical or procedure-related (angiographic) criterion listed below, and none of the exclusion criteria

Clinical criteria (at least one must apply):

• A close blood relative (parent, sibling, or child) who developed heart disease at a young age — before 55 in a male relative or before 65 in a female relative
• A history of more than one heart attack
• Blood test results showing elevated heart-damage proteins (cardiac troponin I or T)
• Hardening or narrowing of arteries in at least one other part of the body, such as the brain or legs
• Type 2 diabetes that is being managed with medication
• Reduced kidney function below a certain level (confirm with trial site for exact values)

Procedure-related (angiographic) criteria (at least one must apply):

• A blockage in the main left heart artery (left main artery) that required a stent
• A blockage near the top of a major heart artery (proximal LAD) that required a stent
• A blockage in a bypass graft (from previous heart bypass surgery) that required a stent
• A total stent length of 60 mm or more across all stents placed
• A previous history of a blood clot forming inside a stent
• A branching artery blockage that required two or more stents
• Blockages in more than two heart arteries that required stents
• A heavily calcified (hardened) blockage that required a special clearing procedure (atherectomy) before stenting
• A complication during the procedure where blood flow to the heart became very slow or stopped temporarily (no-reflow or slow-flow)
• A side branch artery of at least 2 mm that could not have normal blood flow restored during the procedure

Who may not be able to join:

• People who need to take long-term oral blood-thinning medication (anticoagulants)
• People who have a disease of the heart muscle (such as hypertrophic, dilated, or restrictive cardiomyopathy)
• People who have serious irregular heart rhythms requiring an implanted defibrillator (ICD)
• People who have a long-term lung condition such as COPD, asthma, chronic bronchitis, or heart disease caused by lung problems
• People who have a serious active infection such as active hepatitis B, active hepatitis C, or HIV/AIDS
• People who have a blood disorder such as low platelet count, severe anaemia, or leukaemia
• People who have severe liver disease or kidney failure
• People who have or have had a cancer diagnosis
• People who have significant difficulties with memory or thinking (cognitive impairment)
• People who are unwilling or unable to give their consent or attend follow-up appointments

Important: Always verify eligibility with the trial site directly before applying.