Depression and Anxiety Trial, Not Yet Recruiting
voxsanity.com.au · Eligibility summary from public government registries · 18 August 2026 · not medical advice
Who may and may not be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who may be able to join
- People who are able to give informed consent to participate.
- People who are available for the full length of the study and willing to follow all study procedures.
- People aged 18 to 90 years old.
- People who have been diagnosed with major depressive disorder according to DSM-5 standards.
- People whose depressive symptoms are believed to be caused mainly by a major depressive episode, rather than by another neurological or psychiatric condition.
- People who have tried at least 2 different types of antidepressant treatments without success or who could not tolerate them (this can include talking therapies or brain stimulation treatments).
- People who meet the medical requirements to receive ECT (electroconvulsive therapy), including having any relevant medical conditions managed and any required medical tests or clearances completed.
- People who are able to give voluntary consent to treatment.
- People who score at least 2 on a specific item of a depression rating scale called the MADRS (confirm with trial site for details).
- People who are able to sit or lie still for an extended period of time and are willing to follow the theta burst stimulation (a type of brain stimulation) protocol.
Who may not be able to join
Each point below is a reason the trial team may not be able to accept someone. It is not a list of requirements to meet.
- People who have implanted metal devices or materials in their body, such as a heart pacemaker, cochlear implant, deep brain stimulation device, vagus nerve stimulation device, shrapnel, face or scalp piercings that cannot be removed, or metallic tattoos on the face or head.
- People who are pregnant or breastfeeding.
- People who have previously had a bad reaction or could not tolerate transcranial magnetic stimulation (a type of brain stimulation).
- People who have had a fever or illness with fever within the past week.
- People who have received another experimental drug or treatment within the past 30 days.
- People who have had a substance abuse problem or substance use disorder within the past 6 months, not including tobacco use or occasional cannabis use.
- People with a history of epilepsy or seizures.
- People with a history of a penetrating brain injury, multiple sclerosis, brain surgery, or bleeding inside the skull.
- People whose depressive symptoms are more likely caused by another psychiatric, medical, or neurological condition, including severe personality disorder or a psychotic illness.
- People with a severe or moderate intellectual disability.
- People with a major neurocognitive disorder (a significant decline in memory or thinking abilities).
- People who are being held involuntarily or for whom an involuntary ECT treatment order has been filed.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Nicholas Trapp, MD, University of Iowa
Phone: (319) 384-9302
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Primary endpoints
Retention rate at completion of aiTBS vs the ECT group
Can't join this trial?
Data last synced from ClinicalTrials.gov: 30 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.