NCT04491006

Who might be able to join this trial:

• You are between 55 and 85 years old
• You have been diagnosed with mild-to-moderate Alzheimer's disease dementia, based on recognised medical guidelines
• Your memory and thinking scores fall within a specific range, as measured by standard tests given at the screening visit
• You have a reliable family member, friend, or caregiver who can support you throughout the trial
• You are either not currently taking any Alzheimer's medication, OR you have been on a stable approved dose of a specific type of Alzheimer's medication (called a cholinesterase inhibitor) for at least 3 months before screening, OR you stopped taking that type of medication at least 4 weeks before screening

Who may not be able to join:

• You have a history of another significant brain or neurological condition (other than Alzheimer's) that affects thinking or memory
• You have a history of unexplained blackouts or seizures (unless they were caused by a high fever)
• You have an unusual or atypical form of Alzheimer's disease, if this is known from your medical history
• A previous brain MRI scan showed significant abnormalities unrelated to Alzheimer's
• Your hearing is not at a level suitable for a specific type of brain response test used in this trial (confirm with trial site)
• You have been diagnosed with severe clinical depression, even without additional symptoms such as hallucinations
• You are considered to be at significant risk of suicide
• You have been diagnosed with, or treated for, psychosis in the last 2 years
• You had a heart attack or unstable chest pain within the last 6 months
• You have a significant heart rhythm problem, heart muscle disease, or electrical conduction problem in your heart (note: having a pacemaker is acceptable)
• You have high blood pressure above a certain level, or low blood pressure that causes symptoms
• You had a significant abnormal heart trace (ECG) result at your screening visit
• Your kidneys are not functioning well enough, based on a specific blood test result
• Your liver is not functioning well enough, based on specific blood test results or a recognised liver disease scoring system
• You have had a cancerous tumour within the 3 years before screening
• You have taken a medication called memantine (in any form or dose) within 4 weeks before screening
• You have taken a specific high dose (23 mg) of a medication called donepezil
• You have ever received a vaccine for Alzheimer's disease, or have received certain Alzheimer's antibody treatments within 6 months of screening

Important: Always verify eligibility with the trial site directly before applying.