Phase 2 Cardiomyopathy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 21 and 80 years old (inclusive)
• Your kidneys are working at a reduced but not completely failed level, based on a specific kidney function test result (eGFR between 15 and 75)
• A urine test shows a certain level of protein leaking into your urine (albumin-to-creatinine ratio above 30 mg/g)
• If your urine protein level is higher (above 300 mg/g), you are already taking the highest dose of a blood pressure/kidney-protecting medication you can tolerate (an ACE inhibitor or ARB)
• If your doctor recommends it, you are already taking a type of diabetes/kidney medication called an SGLT-2 inhibitor
• You are willing and able to sign a consent form and follow the study plan

Who may not be able to join:

• You have had a bad reaction or allergy to colchicine in the past
• You were in the hospital for any reason in the last 30 days
• You have an urgent medical condition that needs immediate treatment right now
• You have moderate or advanced heart failure (Stage C or D)
• Your heart is pumping less than 40% of its normal capacity
• You have heart valve disease that is causing symptoms
• You were born with a heart defect, whether or not it has been repaired
• You have previously had a heart transplant
• Your kidneys have completely failed, meaning you have had a kidney transplant or you are on dialysis (hemodialysis or peritoneal dialysis)
• Your kidney function has gotten significantly worse in the last 30 days or the last 7 days
• You have taken anti-inflammatory or immune-suppressing medications in the last 30 days (with some limited exceptions for short-term use — confirm with trial site)
• You have Familial Mediterranean Fever, a gout flare within the last 12 months, pericarditis, or another condition that would normally be treated with colchicine
• You have taken antibiotics or other antimicrobial medicines in the last 30 days, or you currently have an active infection
• You have a history of breathing or lung problems that a doctor believes could raise your risk of pneumonia
• You had surgery in the last 30 days, or you have surgery planned during the study period
• You currently have cancer, or you have been treated for cancer within the last year
• A doctor believes that your overall health or life expectancy due to serious illness would make participation too risky
• Your white blood cell (neutrophil) count is too low, based on a blood test
• Your platelet count is too low, based on a blood test
• You are taking certain medications that can interact dangerously with colchicine, such as cyclosporine, clarithromycin, diltiazem, verapamil, itraconazole, ritonavir, digoxin, or others — including regular grapefruit juice (confirm with trial site)
• You are taking certain cholesterol or fat-lowering medications (such as simvastatin, gemfibrozil, or fenofibrate), or a blood test shows your muscle enzyme levels are too high
• You have moderate or severe liver disease
• You are pregnant, breastfeeding, or are unwilling or unable to use appropriate contraception during the study

Important: Always verify eligibility with the trial site directly before applying.