Gastroparesis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

If you have gastroparesis symptoms:

• You are willing and able to sign a consent form and take part in the full study
• You are between 18 and 85 years old
• You have symptoms of gastroparesis caused either by diabetes or by an unknown reason
• Your gastroparesis symptoms score at least 2.0 on a standard symptom rating scale called the GCSI
• You have already had a stomach-emptying scan (a 4-hour test using a small amount of radiation) done for your own medical care within the last 6 months — this scan is not part of the research itself
• You are willing not to start any new treatments until the study procedures are finished
• You are willing to stop certain medications (including antacids, stomach-motility drugs, opioid painkillers, anticholinergics, laxatives, proton pump inhibitors, cannabis products, and others) for 3 days before each visit
• You are willing to avoid all food and water from midnight before each visit (at least 8 hours of fasting) until after the visit is done

If you are a healthy comparison (control) participant:

• You are willing and able to sign a consent form
• You are 18 years old or older
• You are already scheduled for an upper stomach camera procedure (endoscopy) as part of your own medical care, for reasons such as diarrhea, GI bleeding, low iron levels, or preparation for weight-loss surgery
• You do not have significant upper stomach symptoms (scoring no more than 1 on the GCSI symptom scale)

Who may not be able to join:

• You have previously had surgery on your esophagus or stomach, including a procedure called Nissen fundoplication
• You have previously had surgery or a procedure on the valve between your stomach and small intestine (the pylorus)
• You have a known history of a swallowing disorder called achalasia, or a narrowing of the esophagus
• You have a known blockage or obstruction anywhere in your digestive tract
• A previous stomach camera procedure found ulcers in your esophagus, stomach, or upper small intestine, or enlarged veins in your esophagus (varices)
• You have severe lung disease or a large amount of food stuck in your stomach, which could make the procedure more complicated
• You have significant disease or damage in your stomach or upper small intestine that could affect how your stomach moves
• You have another long-term illness that could be causing your digestive symptoms (confirm with trial site)
• You have kidney problems, either short-term or long-term
• You currently have an eating disorder
• You are pregnant (a urine pregnancy test will be done before the procedure for all women)
• You have any condition that makes it unsafe for you to have a stomach camera procedure, including problems with blood clotting
• You are allergic to eggs, which would prevent the use of a common sedation medication (propofol) and may affect the stomach-emptying test
• You have significant difficulty swallowing
• You have a history of inflammatory bowel disease or Crohn's disease
• You have ever had botulinum toxin (Botox) injected into your esophagus, stomach, or pylorus
• You take opioid painkillers every day, or more than 3 days per week
• You currently take certain diabetes or blood sugar medications, including GLP-1 receptor agonists (such as semaglutide), SGLT2 inhibitors, or GIP/GLP combination drugs

Important: Always verify eligibility with the trial site directly before applying.